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Cefpiramide acid
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Catalog No. T0138Cas No. 70797-11-4
Alias Cefpiramidum, Cefpiramido
Cefpiramide acid (Cefpiramidum) is a third-generation cephalosporin antibiotic.
Cefpiramide acid
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Purity: 97.40%
Catalog No. T0138Alias Cefpiramidum, CefpiramidoCas No. 70797-11-4
Cefpiramide acid (Cefpiramidum) is a third-generation cephalosporin antibiotic.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $38 | In Stock | In Stock | |
| 10 mg | $50 | In Stock | In Stock | |
| 25 mg | $68 | In Stock | In Stock | |
| 50 mg | $109 | In Stock | In Stock | |
| 100 mg | $143 | In Stock | In Stock | |
| 200 mg | $201 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $58 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:97.40%
Appearance:Solid
Color:White
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Product Introduction
Cefpiramide acid AI Summary
Cefpiramide acid is a multi-functional compound exhibiting diverse bioactivities across several contexts. It shows species-dependent pharmacokinetics with varying volumes of distribution and clearance rates; notably, it has a lower volume of distribution and clearance in humans and monkeys compared to rats and dogs. As a potent inhibitor of the vitamin D receptor (VDR) with a potency of 39810.7 nM, Cefpiramide acid also demonstrates significant delayed death inhibition of the malarial parasite plastid, exhibiting a potency of 13459.1 nM after 96 hours.
The compound demonstrates moderate liver toxicity with hepatotoxic effects observed in clinical trials, manifesting as acute and cytolytic liver toxicity without indications of severe hepatitis or chronic liver disease. In addition, Cefpiramide acid possesses potent antibacterial properties, particularly against tolC-deficient Escherichia coli (MIC of 0.5 ug.mL-1) and demonstrates activity against wild-type Staphylococcus aureus with a MIC of 32.0 ug.mL-1, which increases in the presence of human serum albumin (HSA).
Bioactivity studies also indicate its involvement in hepatic drug metabolism, excretion, and clearance processes in human, dog, and rat models. Notably, the compound has a low fraction unbound in human plasma (0.09%) compared to dog plasma (0.6%), highlighting differences in binding affinity or bioavailability across species. While showing moderate inhibition of cell viability in Vero E6 cells infected with SARS-CoV-2, its antiviral activity against the SARS-CoV-2 USA-WA1/2020 strain is below the hit threshold. Furthermore, Cefpiramide acid exhibits inhibition of the human HDAC6 enzyme, with differing inhibition percentages depending on the assay substrate used.
Overall, Cefpiramide acid showcases a range of bioactivities from antibacterial and antiviral properties to liver toxicity and enzyme inhibition, dependent on the context and specific biological system evaluated..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Cefpiramide acid (Cefpiramidum) is a third-generation cephalosporin antibiotic. |
| Synonyms | Cefpiramidum, Cefpiramido |
| Molecular Weight | 612.64 |
| Formula | C25H24N8O7S2 |
| Cas No. | 70797-11-4 |
| Smiles | [H][C@]12SCC(CSc3nnnn3C)=C(N1C(=O)[C@H]2NC(=O)[C@H](NC(=O)c1cnc(C)cc1O)c1ccc(O)cc1)C(O)=O |
| Relative Density. | 1.75 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 27.5 mg/mL (44.89 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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