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TC14012 TFA

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Catalog No. T75801

TC14012 TFA, a serum-stable derivative of T140, is a selective peptidomimetic CXCR4 antagonist with an IC50 value of 19.3 nM and also functions as a potent CXCR7 agonist, exhibiting an EC50 of 350 nM for recruiting β-arrestin 2 to CXCR7. This compound demonstrates anti-HIV and anti-cancer activities [1] [2].

TC14012 TFA
Other Forms of TC14012 TFA:

TC14012 TFA

😃Good
Catalog No. T75801
TC14012 TFA, a serum-stable derivative of T140, is a selective peptidomimetic CXCR4 antagonist with an IC50 value of 19.3 nM and also functions as a potent CXCR7 agonist, exhibiting an EC50 of 350 nM for recruiting β-arrestin 2 to CXCR7. This compound demonstrates anti-HIV and anti-cancer activities [1] [2].
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Product Introduction

Bioactivity
Description
TC14012 TFA, a serum-stable derivative of T140, is a selective peptidomimetic CXCR4 antagonist with an IC50 value of 19.3 nM and also functions as a potent CXCR7 agonist, exhibiting an EC50 of 350 nM for recruiting β-arrestin 2 to CXCR7. This compound demonstrates anti-HIV and anti-cancer activities [1] [2].
Chemical Properties
Molecular Weight2180.44
FormulaC92H141F3N34O21S2
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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