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ZWZH-21
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Catalog No. T212544Cas No. 3069195-42-9
WZH-21 is a selective and orally active dual HDAC1/2 inhibitor, exhibiting an IC50 of 34 nM for HDAC1 and 41 nM for HDAC2. It inhibits the growth of HCT116 and SW480 cells with IC50 values of 0.524 μM and 1.063 μM, respectively. WZH-21 suppresses proliferation and migration of various colorectal cancer cells and induces apoptosis (apoptosis). It is applicable in cancer research, including studies on colorectal cancer.
ZWZH-21
😃Good
Catalog No. T212544Cas No. 3069195-42-9
WZH-21 is a selective and orally active dual HDAC1/2 inhibitor, exhibiting an IC50 of 34 nM for HDAC1 and 41 nM for HDAC2. It inhibits the growth of HCT116 and SW480 cells with IC50 values of 0.524 μM and 1.063 μM, respectively. WZH-21 suppresses proliferation and migration of various colorectal cancer cells and induces apoptosis (apoptosis). It is applicable in cancer research, including studies on colorectal cancer.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | WZH-21 is a selective and orally active dual HDAC1/2 inhibitor, exhibiting an IC50 of 34 nM for HDAC1 and 41 nM for HDAC2. It inhibits the growth of HCT116 and SW480 cells with IC50 values of 0.524 μM and 1.063 μM, respectively. WZH-21 suppresses proliferation and migration of various colorectal cancer cells and induces apoptosis (apoptosis). It is applicable in cancer research, including studies on colorectal cancer. |
| Targets&IC50 | HDAC1:34 nM |
| In vitro | ZWZH-21 effectively inhibits the growth of A549, MCF-7, and HepG2 cells, with IC 50 values of 1.66 μM, 2.445 μM, and 1.551 μM respectively. It suppresses the temperature-induced degradation of HDAC1/2 in HCT116 cells at concentrations of 0.4-1.6 μM over 48 hours. This compound also induces the degradation of HDAC1 and HDAC2 proteins and the formation of Ac-H3 and histone H4 in a concentration-dependent manner within HCT116 cells. ZWZH-21 reduces the colony-forming ability of HCT116 and SW480 cells and inhibits their migration while inducing apoptosis when applied at 0.4-2 μM for 48 hours. Additionally, ZWZH-21 triggers G1 phase arrest in HCT116 and SW480 cells under similar conditions. |
| In vivo | ZWZH-21 (2000 mg/kg, single oral dose) has demonstrated good safety in mice. In addition, ZWZH-21 (30-120 mg/kg, via gavage, administered daily for 14 days) effectively inhibited tumor growth in mice implanted with HCT116 human colon cancer xenografts. |
| Molecular Weight | 422.48 |
| Formula | C26H22N4O2 |
| Cas No. | 3069195-42-9 |
| Smiles | O=C(NC=1C=CC=CC1N)C2=CC=C(OCCN3C=4C=NC=CC4C=5C=CC=CC53)C=C2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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