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Prednisolone acetate

Name: Prednisolone acetate
Brand: TargetMol
SKU: T0337
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0337Cas No. 52-21-1

Alias Prednisolone-21-acetate, Omnipred

Prednisolone acetate (Omnipred) is the acetate salt form of prednisolone, a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.

Prednisolone acetate

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Purity: 99.12%

Catalog No. T0337Alias Prednisolone-21-acetate, OmnipredCas No. 52-21-1

Prednisolone acetate (Omnipred) is the acetate salt form of prednisolone, a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$30	In Stock	In Stock
500 mg	$44	In Stock	In Stock
1 g	$64	In Stock	In Stock
5 g	$155	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.12%

Appearance:solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Prednisolone acetate AI Summary

Prednisolone acetate exhibits a diverse range of bioactivities. It shows a binding affinity against the human monoclonal antibody (mAb)-7F2 with an IC50 of 12000.0. It demonstrates potency similar to fluocinolone 16,17-acetonide in the human vasoconstrictor test and an anti-inflammatory effect in the rat granuloma assay, exhibiting a potency of 3.0 relative to hydrocortisone. The compound has an intrinsic aqueous solubility of logS0 = -4.37 at pH 10 and binds to beta cyclodextrin with a log Ks value of 3.76. Prednisolone acetate modulates or inhibits various pathways and targets, including miR-21, Nrf2, Chronic Active B-Cell Receptor Signaling, and others, with potencies ranging from 25.1 nM to 89125.1 nM. It significantly inhibits sodium fluorescein uptake in OATP1B3-transfected CHO cells (106.69% inhibition at 10µM) and moderately in OATP1B1-transfected CHO cells (63.69% inhibition at 10µM). The compound shows antiviral activity against SARS-CoV-2, inhibiting cytotoxicity in Caco-2 cells (59.99% at 10µM) and 3CL-Pro protease (38.15% at 20µM). It also demonstrates antifungal and antibacterial activities, notably against Acinetobacter baumannii (25.62% inhibition), but shows negligible activity against other pathogens like Cryptococcus neoformans and low antiviral activity in VERO-6 cells. The broad bioactivity spectrum highlights its potential therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Prednisolone acetate (Omnipred) is the acetate salt form of prednisolone, a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
Synonyms	Prednisolone-21-acetate, Omnipred

Chemical Properties

Molecular Weight	402.48
Formula	C₂₃H₃₀O₆
Cas No.	52-21-1
Smiles	[H][C@@]12CC[C@](O)(C(=O)COC(C)=O)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)C=C[C@]12C
Relative Density.	1.28 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 50 mg/mL (124.23 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (6.21 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4846 mL	12.4230 mL	24.8460 mL	124.2298 mL
5 mM	0.4969 mL	2.4846 mL	4.9692 mL	24.8460 mL
10 mM	0.2485 mL	1.2423 mL	2.4846 mL	12.4230 mL
20 mM	0.1242 mL	0.6211 mL	1.2423 mL	6.2115 mL
50 mM	0.0497 mL	0.2485 mL	0.4969 mL	2.4846 mL
100 mM	0.0248 mL	0.1242 mL	0.2485 mL	1.2423 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc