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BChE/p38-α MAPK-IN-1
Catalog No. T212999 Copy Product Info
🥰Excellent
BChE/p38-α MAPK-IN-1 is a selective dual inhibitor targeting hBChE (IC50 = 772 nM) and p38α MAPK (IC50 = 191 nM). It reduces the production of pro-inflammatory cytokines (IL-1β, IL-6, IL-8, TNF-α) in cells, improves scopolamine-induced cognitive impairment, alleviates LPS-induced spatial learning deficits, and exhibits anti-neuroinflammatory effects in mice, making it applicable for Alzheimer's disease (AD) research.
BChE/p38-α MAPK-IN-1
Copy Product Info🥰Excellent
Catalog No. T212999
BChE/p38-α MAPK-IN-1 is a selective dual inhibitor targeting hBChE (IC50 = 772 nM) and p38α MAPK (IC50 = 191 nM). It reduces the production of pro-inflammatory cytokines (IL-1β, IL-6, IL-8, TNF-α) in cells, improves scopolamine-induced cognitive impairment, alleviates LPS-induced spatial learning deficits, and exhibits anti-neuroinflammatory effects in mice, making it applicable for Alzheimer's disease (AD) research.
BChE/p38-α MAPK-IN-1
Cas No. 3077831-11-6
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | BChE/p38-α MAPK-IN-1 is a selective dual inhibitor targeting hBChE (IC50 = 772 nM) and p38α MAPK (IC50 = 191 nM). It reduces the production of pro-inflammatory cytokines (IL-1β, IL-6, IL-8, TNF-α) in cells, improves scopolamine-induced cognitive impairment, alleviates LPS-induced spatial learning deficits, and exhibits anti-neuroinflammatory effects in mice, making it applicable for Alzheimer's disease (AD) research. |
| Targets&IC50 | p38α MAPK:191 nM |
| In vitro | BChE/p38-α MAPK-IN-1 (Compound 95) exhibits inhibitory activity against hBChE (IC50 = 772 nM) and p38α MAPK (IC50 = 191 nM). At concentrations of 1-5 μM over 18 hours, it reduces the production of pro-inflammatory cytokines (IL-1β, IL-6, IL-8, TNF-α) in phytohemagglutinin (PHA)-stimulated human peripheral blood mononuclear cells (PBMCs) and slightly increases the anti-inflammatory cytokine IL-12. |
| In vivo | BChE/p38-α MAPK-IN-1 (Compound 95), when administered intraperitoneally at 5-10 mg/kg 60 minutes prior to testing, improves scopolamine-induced cognitive impairment in adult male albino Swiss (CD-1) mice. Additionally, BChE/p38-α MAPK-IN-1, at a dosage of 10 mg/kg via intraperitoneal injection once daily for 10 days, alleviates spatial learning deficits induced by LPS and exhibits anti-neuroinflammatory effects in adult male C57BL/6J mice. |
| Molecular Weight | 454.57 |
| Formula | C26H32F2N4O |
| Cas No. | 3077831-11-6 |
| Smiles | O=C(NCCN(C)C)C1=CC2=C(C=NN2CC3CCCCC3)C=C1CC4=CC=C(F)C=C4F |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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