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Harmalol hydrochloride

Name: Harmalol hydrochloride
Brand: TargetMol
SKU: TN1724
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. TN1724Cas No. 6028-07-5

Alias Harmidol hydrochloride

Harmalol hydrochloride (Harmidol hydrochloride) is a β-carboline alkaloid that can be extracted from the seeds of Peganum harmala L. Harmalol hydrochloride is the major metabolite of Harmaline and significantly inhibits dioxin-mediated induction of CYP1A1 at both transcriptional and post-translational levels. Harmalol hydrochloride showed vasorelaxant activity in isolated rat thoracic aortic preparations preconstricted with phenylephrine or KCl. Harmalol hydrochloride has antioxidant activity.

Harmalol hydrochloride

🥰Excellent

Purity: 99.43%

Catalog No. TN1724Alias Harmidol hydrochlorideCas No. 6028-07-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$34	-	In Stock
5 mg	$77	-	In Stock
10 mg	$123	-	In Stock
25 mg	$247	-	In Stock
50 mg	$372	-	In Stock
1 mL x 10 mM (in DMSO)	$84	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.43%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Harmalol hydrochloride (Harmidol hydrochloride) is a β-carboline alkaloid that can be extracted from the seeds of Peganum harmala L. Harmalol hydrochloride is the major metabolite of Harmaline and significantly inhibits dioxin-mediated induction of CYP1A1 at both transcriptional and post-translational levels. Harmalol hydrochloride showed vasorelaxant activity in isolated rat thoracic aortic preparations preconstricted with phenylephrine or KCl. Harmalol hydrochloride has antioxidant activity.
Targets&IC50	MAO-A:0.66 μM, H4 human glioblastoma:23.7 μM(IC50s), DYRK1A:0.63 μM
In vitro	Harmalol (0.5-12.5 μM) reduces increases in the levels of the cytochrome P450 (CYP) isoform CYP1A1 induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells and prevents TCDD-induced activation of the aryl hydrocarbon receptor (AhR) in guinea pig hepatic cytosolic extracts.[1] Harmalol (25 μM) reduces glutamate-induced cytotoxicity, cytochrome c release, caspase-3 activation, and the production of reactive oxygen species (ROS) in PC12 cells.[2]
Synonyms	Harmidol hydrochloride

Chemical Properties

Molecular Weight	236.7
Formula	C₁₂H₁₃ClN₂O
Cas No.	6028-07-5
Smiles	Cl.CC1=NCCc2c1[nH]c1cc(O)ccc21
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90.0 mg/mL (380.2 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2248 mL	21.1238 mL	42.2476 mL	211.2379 mL
5 mM	0.8450 mL	4.2248 mL	8.4495 mL	42.2476 mL
10 mM	0.4225 mL	2.1124 mL	4.2248 mL	21.1238 mL
20 mM	0.2112 mL	1.0562 mL	2.1124 mL	10.5619 mL
50 mM	0.0845 mL	0.4225 mL	0.8450 mL	4.2248 mL
100 mM	0.0422 mL	0.2112 mL	0.4225 mL	2.1124 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc