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IMP-1710

Catalog No. T37591 CAS 2383117-96-0

IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.

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IMP-1710, CAS 2383117-96-0

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.
Targets&IC50	UCH-L1:38 nM (fluorescence polarization assay)
In vitro	IMP-1710 inhibits TGF-β1-induced fibroblast-to-myofibroblast transition in primary lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis with an IC50 value of 740 nM[1].

Molecular Weight	381.43
Formula	C23H19N5O
CAS No.	2383117-96-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

Ethanol: 4.5 mg/mL (11.8 mM)

Chloroform: 9.0 mg/mL (23.6 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Panyain, N., Godinat, A., Lanyon-Hogg, T., et al.Discovery of a potent and selective covalent inhibitor and activity-based probe for the deubiquitylating enzyme UCHL1, with antifibrotic activityJ. Am. Chem. Soc.142(28)12020-12026(2020)

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

IMP-1710 2383117-96-0 Cell Cycle/Checkpoint DNA Damage/DNA Repair Ubiquitination DUB IMP1710 IMP 1710 Inhibitor inhibitor inhibit

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