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IMP-1710

Name: IMP-1710
Brand: TargetMol
SKU: T37591
Price: 156 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T37591Cas No. 2383117-96-0

IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.IMP-1710 has antifibrotic activity. [1]

IMP-1710

🥰Excellent

Purity: 99.3%

Catalog No. T37591Cas No. 2383117-96-0

IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.IMP-1710 has antifibrotic activity. [1]

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$156	In Stock	In Stock
5 mg	$679	In Stock	In Stock
10 mg	$945	In Stock	In Stock
25 mg	$1,380	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.3%

ee:100%

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COA HNMR CSFC LCMS

Product Introduction

Bioactivity

Description	IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.IMP-1710 has antifibrotic activity. [1]
Targets&IC50	UCHL1:38 nM (fluorescence polarization assay)
In vitro	METHODS: Unbiased quantitative chemical proteome analysis (Figure 22a) was used in HEK293 cells treated with IMP-1710 (2, 20 or 200 nM) or vehicle (DMSO) for 10, 60 or 180 minutes to determine the overall proteome. Selectivity. RESULTS IMP-1710 significantly enriched ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) and fibroblast growth factor receptor 2 (FGFR2) at 20 nM. [1]

Chemical Properties

Molecular Weight	381.43
Formula	C₂₃H₁₉N₅O
Cas No.	2383117-96-0
Smiles	C(=O)(N1C=2C(=C(C=CC2)C=3C=4C(NC3)=NC=C(C#C)C4)CC1)[C@H]5N(C#N)CCC5
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 20 mg/mL (52.43 mM), Sonication is recommended.

Ethanol: 4.5 mg/mL (11.8 mM), Sonication is recommended.

Chloroform: 9 mg/mL (23.6 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.24 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/Chloroform/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6217 mL	13.1086 mL	26.2171 mL	131.0857 mL
5 mM	0.5243 mL	2.6217 mL	5.2434 mL	26.2171 mL
10 mM	0.2622 mL	1.3109 mL	2.6217 mL	13.1086 mL

Chloroform/DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1311 mL	0.6554 mL	1.3109 mL	6.5543 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0524 mL	0.2622 mL	0.5243 mL	2.6217 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc