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IMP-1710

Name: IMP-1710
Brand: TargetMol
SKU: T37591
Price: 156 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T37591Cas No. 2383117-96-0

IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.IMP-1710 has antifibrotic activity. [1]

IMP-1710

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Purity: 99.3%

Catalog No. T37591Cas No. 2383117-96-0

IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.IMP-1710 has antifibrotic activity. [1]

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$156	In Stock	In Stock
5 mg	$679	In Stock	In Stock
10 mg	$945	In Stock	In Stock
25 mg	$1,380	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.3%

ee:100%

Appearance:Solid

Color:White

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COA LCMS CSFC HNMR

Product Introduction

Bioactivity

Description	IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.IMP-1710 has antifibrotic activity. [1]
Targets&IC50	UCHL1:38 nM (fluorescence polarization assay)
In vitro	METHODS: Unbiased quantitative chemical proteome analysis (Figure 22a) was used in HEK293 cells treated with IMP-1710 (2, 20 or 200 nM) or vehicle (DMSO) for 10, 60 or 180 minutes to determine the overall proteome. Selectivity. RESULTS IMP-1710 significantly enriched ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) and fibroblast growth factor receptor 2 (FGFR2) at 20 nM. [1]

Chemical Properties

Molecular Weight	381.43
Formula	C₂₃H₁₉N₅O
Cas No.	2383117-96-0
Smiles	C(=O)(N1C=2C(=C(C=CC2)C=3C=4C(NC3)=NC=C(C#C)C4)CC1)[C@H]5N(C#N)CCC5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 20 mg/mL (52.43 mM), Sonication is recommended.

Ethanol: 4.5 mg/mL (11.8 mM), Sonication is recommended.

Chloroform: 9 mg/mL (23.6 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.24 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/Chloroform/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6217 mL	13.1086 mL	26.2171 mL	131.0857 mL
5 mM	0.5243 mL	2.6217 mL	5.2434 mL	26.2171 mL
10 mM	0.2622 mL	1.3109 mL	2.6217 mL	13.1086 mL

Chloroform/DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1311 mL	0.6554 mL	1.3109 mL	6.5543 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0524 mL	0.2622 mL	0.5243 mL	2.6217 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc