ALK-5 Protein, Human, Recombinant (hFc)

Name: ALK-5 Protein, Human, Recombinant (hFc)
Brand: TargetMol
SKU: TMPY-05771
Rating: 4.5 (1 reviews)

(Synonyms: tβR-I, transforming growth factor, β receptor 1, transforming growth factor, beta receptor 1, TGFR-1, tbetaR-I, SKR4, MSSE, LDS2A, LDS1A, LDS1, ESS1, ALK-5, ALK5, ACVRLK4, AAT5) Copy Product Info

Synonyms: tβR-I, transforming growth factor, β receptor 1, transforming growth factor, beta receptor 1, TGFR-1, tbetaR-I, SKR4, MSSE, LDS2A, LDS1A, LDS1, ESS1, ALK-5, ALK5, ACVRLK4, AAT5

Catalog No. TMPY-05771 Copy Product Info

ALK-5 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 36.87 kDa and the accession number is P36897-1.

Pack Size	Price	USA Stock	Global Stock
5 µg	$68	7-10 days	7-10 days
10 µg	$108	7-10 days	7-10 days
20 µg	$178	7-10 days	7-10 days
50 µg	$357	7-10 days	7-10 days
100 µg	$622	7-10 days	7-10 days
200 µg	$1,070	7-10 days	7-10 days
500 µg	$2,250	7-10 days	7-10 days
1 mg	$4,530	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	ALK-5 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 36.87 kDa and the accession number is P36897-1.
Species	Human
Expression System	HEK293 Cells
Tag	C-hFc
Accession Number	P36897-1
Construction	A DNA sequence encoding the human TGFBR1 isoform 1 precursor (NP_004603.1) (Met1-Leu126) was expressed with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: Leu34
Protein Purity	> 95 % as determined by SDS-PAGE.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	tβR-I, transforming growth factor, β receptor 1, transforming growth factor, beta receptor 1, TGFR-1, tbetaR-I, SKR4, MSSE, LDS2A, LDS1A, LDS1, ESS1, ALK-5, ALK5, ACVRLK4, AAT5
Research Background	Transforming growth factor, beta receptor I, also known as Transforming growth factor-beta receptor type I , Serine / threonine-protein kinase receptor R4, Activin receptor-like kinase 5, SKR4, ALK-5, and TGFBR1, is a single-pass type I membrane protein that belongs to the protein kinase superfamily and TGFB receptor subfamily. TGFBR1 / ALK-5 is found in all tissues examined. It is most abundant in placenta and least abundant in brain and heart. TGF-beta functions as a tumor suppressor by inhibiting the cell cycle in the G1 phase. Administration of TGF-beta is able to protect against mammary tumor development in transgenic mouse models in vivo. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers, with the majority of colon and gastric cancers being caused by an inactivating mutation of TGF-beta RII. On ligand binding, TGFBR1 / ALK-5 forms a receptor complex consisting of two type I I and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which auto-phosphorylate, then bind and activate SMAD transcriptional regulators. TGF-beta signaling via TGFBR1 / ALK-5 is not required in myocardial cells during mammalian cardiac development, but plays an irreplaceable cell-autonomous role regulating cellular communication, differentiation and proliferation in endocardial and epicardial cells. Defects in TGFBR1 / ALK-5 are the cause of Loeys-Dietz syndrome type 1A (LDS1A), Loeys-Dietz syndrome type 2A (LDS2A), and aortic aneurysm familial thoracic type 5 (AAT5).

Chemical Properties

Molecular Weight

36.87 kDa (predicted)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.