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Anti-TRXR1/TXNRD1 Antibody (5M66)
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Catalog No. TMAY-02474
Alias TXNR, TRXR1, TR1, TR, thioredoxin reductase 1, GRIM-12
Anti-TRXR1/TXNRD1 Antibody (5M66) is a Mouse antibody targeting TRXR1/TXNRD1. Anti-TRXR1/TXNRD1 Antibody (5M66) can be used in FCM,ICC/IF.
Anti-TRXR1/TXNRD1 Antibody (5M66)
Anti-TRXR1/TXNRD1 Antibody (5M66)
😃Good
Catalog No. TMAY-02474Alias TXNR, TRXR1, TR1, TR, thioredoxin reductase 1, GRIM-12
Anti-TRXR1/TXNRD1 Antibody (5M66) is a Mouse antibody targeting TRXR1/TXNRD1. Anti-TRXR1/TXNRD1 Antibody (5M66) can be used in FCM,ICC/IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $199 | 7-10 days |
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Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-TRXR1/TXNRD1 Antibody (5M66) is a Mouse antibody targeting TRXR1/TXNRD1. Anti-TRXR1/TXNRD1 Antibody (5M66) can be used in FCM,ICC/IF. |
| Alias | TXNR, TRXR1, TR1, TR, thioredoxin reductase 1, GRIM-12 |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 5M66 |
| Reactivity | Human |
| Verified Activity | 1. Immunofluorescence staining of Human TXNRD1 in Hela cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum, and incubated with mouse anti-Human TXNRD1 monoclonal antibody (1:60) at 37°C 1 hour. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-mouse IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to cytoplasm and nucleus. 2. Flow cytometric analysis of Human TXNRD1 expression on HeLa cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), stained with purified anti-Human C1QBP, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM,ICC/IF |
| Recommended Dose | ICC-IF: 1:20-1:100; FCM: 1:25-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This product is a recombinant monoclonal antibody expressed from HEK293 cells. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Thioredoxin reductase 1 (TXNRD1) which is a selenocysteine-containing protein is overexpressed in many malignancies. TXNRD1 plays a key role in regulating cell growth and transformation, and protects cells against oxidative damage. We investigated the association between TXNRD1 polymorphisms and ATDH susceptibility. Moreover, TXNRD1 is an essential selenium-containing enzyme involved in detoxification of reactive oxygen species (ROS) and redox signaling. And genetic variations in TXNRD1 favor the development of Drug-induced liver injury (DILI), which is the most common adverse drug reaction. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human TXNRD1 protein (TMPY-02271) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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