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HXR9 hydrochloride

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Catalog No. T76213

HXR9 hydrochloride, a cell-permeable peptide and competitive antagonist of the HOX/PBX interaction, selectively reduces cell proliferation and induces apoptosis in cells with elevated HOXA/PBX3 gene expression, notably MLL-rearranged leukemic cells [1] [2] [3]. By inhibiting the interaction between HOX proteins and the transcription factor PBX, which associates with HOX proteins in paralogue groups 1 to 8, it disrupts a critical regulatory mechanism in these cells.

HXR9 hydrochloride
Other Forms of HXR9 hydrochloride:
HXR9T41062917953-08-3
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HXR9 hydrochloride

😃Good
Catalog No. T76213
HXR9 hydrochloride, a cell-permeable peptide and competitive antagonist of the HOX/PBX interaction, selectively reduces cell proliferation and induces apoptosis in cells with elevated HOXA/PBX3 gene expression, notably MLL-rearranged leukemic cells [1] [2] [3]. By inhibiting the interaction between HOX proteins and the transcription factor PBX, which associates with HOX proteins in paralogue groups 1 to 8, it disrupts a critical regulatory mechanism in these cells.
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Product Introduction

Bioactivity
Description
HXR9 hydrochloride, a cell-permeable peptide and competitive antagonist of the HOX/PBX interaction, selectively reduces cell proliferation and induces apoptosis in cells with elevated HOXA/PBX3 gene expression, notably MLL-rearranged leukemic cells [1] [2] [3]. By inhibiting the interaction between HOX proteins and the transcription factor PBX, which associates with HOX proteins in paralogue groups 1 to 8, it disrupts a critical regulatory mechanism in these cells.
Chemical Properties
Molecular Weight2754.67
FormulaC119H194ClN53O20S
SequenceTrp-Tyr-Pro-Trp-Met-Lys-Lys-His-His-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg
Sequence ShortWYPWMKKHHRRRRRRRRR
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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