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PSNCBAM-1

Name: PSNCBAM-1
Brand: TargetMol
SKU: T28468
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28468Cas No. 877202-74-9

Alias PSNCBAM 1

PSNCBAM-1 (PSNCBAM 1) is a CB1 receptor negative allosteric modulator (EC50 = 0.1 μM) with hypophagic effects in vivo. PSNCBAM-1 can be used for obesity studies.

PSNCBAM-1

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Purity: 99.86%

Catalog No. T28468Alias PSNCBAM 1Cas No. 877202-74-9

PSNCBAM-1 (PSNCBAM 1) is a CB1 receptor negative allosteric modulator (EC50 = 0.1 μM) with hypophagic effects in vivo. PSNCBAM-1 can be used for obesity studies.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	In Stock	In Stock
5 mg	$113	In Stock	In Stock
10 mg	$179	In Stock	In Stock
25 mg	$297	In Stock	In Stock
50 mg	$463	In Stock	In Stock
100 mg	$658	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.86%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

PSNCBAM-1 AI Summary

PSNCBAM-1 exhibits multifaceted bioactivities targeting cannabinoid receptors, particularly the human CB1 receptor. It functions as both an antagonist and negative allosteric modulator, with an IC50 of 32.5 nM as an antagonist and an IC50 of 33.0 nM for inhibiting CP55,940-induced calcium mobilization. Additionally, it acts as a positive allosteric modulator, enhancing [3H]CP55,940 binding, with a binding affinity (Kb) of 54.3 nM, and inhibition effects with IC50 values ranging from 42.0 to 89.0 nM, as well as an EC50 of 270.0 nM for [3H]CP55,940 binding induction. The compound also possesses partial agonist activity at the CB1 receptor, showing a 28.2% activity relative to CP55,940. At the CB2 receptor, PSNCBAM-1 demonstrates weak antagonist activity with an IC50 above 10,000 nM and negligible agonist activity with an Emax of less than 10.0%. Aside from its cannabinoid receptor interactions, PSNCBAM-1 exhibits significant antiviral activity, inhibiting SARS-CoV-2 induced cytotoxicity in various cell lines. It achieves an 8.84% inhibition in Caco-2 cells at 10 µM concentration and inhibits the SARS-CoV-2 3CL-Pro protease by 21.22% at 20 µM concentration. The compound also inhibits enzymes like FAAH (IC50 of 2100 nM) and exhibits mixed effects in enzymatic assays of human HDAC6, suggesting varying levels of inhibition depending on the substrate. Furthermore, thermal shift assays indicate that PSNCBAM-1 influences the thermal stability of specific domains, with mixed increases and decreases in thermal stability. In conclusion, PSNCBAM-1 is a complex bioactive molecule with notable interactions at human cannabinoid receptors, marked by both antagonist and modulator activities, alongside antiviral and enzyme inhibition properties..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	PSNCBAM-1 (PSNCBAM 1) is a CB1 receptor negative allosteric modulator (EC50 = 0.1 μM) with hypophagic effects in vivo. PSNCBAM-1 can be used for obesity studies.
Targets&IC50	CB1 receptor (human):0.1 μM (EC50)
Synonyms	PSNCBAM 1

Chemical Properties

Molecular Weight	392.88
Formula	C₂₂H₂₁ClN₄O
Cas No.	877202-74-9
Smiles	N(C(NC1=CC=C(Cl)C=C1)=O)C=2C=C(C=3N=C(C=CC3)N4CCCC4)C=CC2
Relative Density.	1.332 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (139.99 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5453 mL	12.7265 mL	25.4531 mL	127.2653 mL
5 mM	0.5091 mL	2.5453 mL	5.0906 mL	25.4531 mL
10 mM	0.2545 mL	1.2727 mL	2.5453 mL	12.7265 mL
20 mM	0.1273 mL	0.6363 mL	1.2727 mL	6.3633 mL
50 mM	0.0509 mL	0.2545 mL	0.5091 mL	2.5453 mL
100 mM	0.0255 mL	0.1273 mL	0.2545 mL	1.2727 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc