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Anti-UBE2D4 Antibody (4Q854)

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Catalog No. TMAY-02536
Alias ubiquitin-conjugating enzyme E2D 4 (putative), HBUCE1

Anti-UBE2D4 Antibody (4Q854) is a Rabbit antibody targeting UBE2D4. Anti-UBE2D4 Antibody (4Q854) can be used in ELISA.

Anti-UBE2D4 Antibody (4Q854)

Anti-UBE2D4 Antibody (4Q854)

😃Good
Catalog No. TMAY-02536Alias ubiquitin-conjugating enzyme E2D 4 (putative), HBUCE1
Anti-UBE2D4 Antibody (4Q854) is a Rabbit antibody targeting UBE2D4. Anti-UBE2D4 Antibody (4Q854) can be used in ELISA.
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100 μL$269 7-10 days
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Product Introduction

Bioactivity
Description
Anti-UBE2D4 Antibody (4Q854) is a Rabbit antibody targeting UBE2D4. Anti-UBE2D4 Antibody (4Q854) can be used in ELISA.
Aliasubiquitin-conjugating enzyme E2D 4 (putative), HBUCE1
Ig Type
Monoclonal Rabbit IgG
Clone
4Q854
Reactivity
Human
Application
ELISA
Recommended Dose
ELISA: 1:5000-1:10000
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionThis antibody was obtained from a rabbit immunized with purified, recombinant Human UBE2D4 (rh UBE2D4; TMPY-02604; Q9Y2X8; Met1-Met1474).
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundUBE2D4 is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed nowadays to be crucial for a wider range of cellular processes. The outcome of the ubiquitin-conjugation reaction, and thereby the fate of the substrate, is heavily dependent on the number of ubiquitin molecules attached and how these ubiquitin molecules are inter-connected. To deal with this complexity and to allow adequate ubiquitination in time and space, a highly sophisticated conjugation machinery has been developed. In a sequential manner, ubiquitin becomes activated by a ubiquitin-activating enzyme (E1), which then transfers the ubiquitin to a group of ubiquitin-conjugating enzymes (E2s). Next, ubiquitin-loaded E2s are interacting with ubiquitin-protein ligases (E3s) and ubiquitin is conjugated to substrates on recruitment by the E3. These three key enzymes are operating in a hierarchical system, wherein two E1s and 35 E2s have been found and hundreds of E3s have been identified in humans. It has been identified the UBE2D family (UBE2D1-4) as E2 partners for IDOL that support both autoubiquitination and IDOL-dependent ubiquitination of the LDLR in a cell-free system.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Human UBE2D4 protein (TMPY-02604)
Antigen Species
Human
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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