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Anti-UBE2D4 Antibody (4Q854)
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Catalog No. TMAY-02536
Alias ubiquitin-conjugating enzyme E2D 4 (putative), HBUCE1
Anti-UBE2D4 Antibody (4Q854) is a Rabbit antibody targeting UBE2D4. Anti-UBE2D4 Antibody (4Q854) can be used in ELISA.
Anti-UBE2D4 Antibody (4Q854)
Anti-UBE2D4 Antibody (4Q854)
😃Good
Catalog No. TMAY-02536Alias ubiquitin-conjugating enzyme E2D 4 (putative), HBUCE1
Anti-UBE2D4 Antibody (4Q854) is a Rabbit antibody targeting UBE2D4. Anti-UBE2D4 Antibody (4Q854) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: ELISA Reactivity: Human |
| Alias | ubiquitin-conjugating enzyme E2D 4 (putative), HBUCE1 |
| Ig Type | Rabbit IgG |
| Clone | 4Q854 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human UBE2D4 (rh UBE2D4; TMPY-02604; Q9Y2X8; Met1-Met1474). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | UBE2D4 is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed nowadays to be crucial for a wider range of cellular processes. The outcome of the ubiquitin-conjugation reaction, and thereby the fate of the substrate, is heavily dependent on the number of ubiquitin molecules attached and how these ubiquitin molecules are inter-connected. To deal with this complexity and to allow adequate ubiquitination in time and space, a highly sophisticated conjugation machinery has been developed. In a sequential manner, ubiquitin becomes activated by a ubiquitin-activating enzyme (E1), which then transfers the ubiquitin to a group of ubiquitin-conjugating enzymes (E2s). Next, ubiquitin-loaded E2s are interacting with ubiquitin-protein ligases (E3s) and ubiquitin is conjugated to substrates on recruitment by the E3. These three key enzymes are operating in a hierarchical system, wherein two E1s and 35 E2s have been found and hundreds of E3s have been identified in humans. It has been identified the UBE2D family (UBE2D1-4) as E2 partners for IDOL that support both autoubiquitination and IDOL-dependent ubiquitination of the LDLR in a cell-free system. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human UBE2D4 protein (TMPY-02604) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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