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Anti-CD130 Polyclonal Antibody
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Catalog No. TMAB-03837
Anti-CD130 Polyclonal Antibody is a Rabbit antibody targeting CD130. Anti-CD130 Polyclonal Antibody can be used in WB,ELISA,ICC/IF.
Anti-CD130 Polyclonal Antibody
Anti-CD130 Polyclonal Antibody
😃Good
Catalog No. TMAB-03837
Anti-CD130 Polyclonal Antibody is a Rabbit antibody targeting CD130. Anti-CD130 Polyclonal Antibody can be used in WB,ELISA,ICC/IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $371 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-CD130 Polyclonal Antibody is a Rabbit antibody targeting CD130. Anti-CD130 Polyclonal Antibody can be used in WB,ELISA,ICC/IF. |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | WB: 1:500-2000; ELISA: 1:5000-10000; ICC/IF: 1:50 - 1:200 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. |
| Tissue Specificity | Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells. |
| Construction | Hybridoma Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | bs-1459P is one synthetic peptide derived from human IL6R beta. CD130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. |
| Immunogen | Recombinant Protein: human CD130 protein |
| Antigen Species | Human |
| Gene Name | IL6ST |
| Gene ID | |
| Protein Name | Interleukin-6 receptor subunit beta |
| Uniprot ID | |
| Function | Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events. |
| Molecular Weight | Theoretical: 103 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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