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Chlorhexidine digluconate

Name: Chlorhexidine digluconate
Brand: TargetMol
SKU: T14951
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14951Cas No. 18472-51-0

Chlorhexidine digluconate is a broad-spectrum antiseptic and disinfectant with broad-spectrum antimicrobial activity, inhibits both Gram-positive and Gram-negative bacteria, induces necrosis and apoptosis, and can be used in the study of bacterial infections.

Chlorhexidine digluconate

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Purity: 98.53%

Catalog No. T14951Cas No. 18472-51-0

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	Inquiry	-	In Stock
1 g	Inquiry	-	In Stock
5 g	$40	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.53%

Appearance:Liquid

Color:Transparent

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COA HPLC

Product Introduction

Bioactivity

Description	Chlorhexidine digluconate is a broad-spectrum antiseptic and disinfectant with broad-spectrum antimicrobial activity, inhibits both Gram-positive and Gram-negative bacteria, induces necrosis and apoptosis, and can be used in the study of bacterial infections.
In vitro	Chlorhexidine digluconate exhibits dose-dependent and time-dependent effects on Chinese hamster ovary (CHO) cells (P < 0.05). As the concentration of Chlorhexidine digluconate increases, the mode of cell death shifts from apoptosis to necrosis: Chlorhexidine digluconate (0.00005%, 0.0001%, 0.0005%; 1 hour) induces approximately 1.62%, 5.51%, and 5.47% apoptosis, while the percentages of cell necrosis are 2.38%, 8.62%, and 22.50%, respectively.[1].
In vivo	Compared to mice in group D receiving only saline lavage, a single intraperitoneal injection of Chlorhexidine gluconate (0.05%, 0.025%) significantly reduces the incidence of intra-abdominal abscess formation after lavage surgery. There is no significant difference in the incidence of gross adhesions between groups of mice that have or have not undergone surgery[2].

Chemical Properties

Molecular Weight	897.76
Formula	C₃₄H₅₄Cl₂N₁₀O₁₄
Cas No.	18472-51-0
Smiles	ClC(C=C1)=CC=C1NC(NC(NCCCCCCNC(NC(NC2=CC=C(C=C2)Cl)=N)=N)=N)=N.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O
Relative Density.	1.06g/mLat 25°C(lit.)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (278.47 mM), Sonication is recommended.

H2O: 80 mg/mL (89.11 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1139 mL	5.5694 mL	11.1388 mL	55.6942 mL
5 mM	0.2228 mL	1.1139 mL	2.2278 mL	11.1388 mL
10 mM	0.1114 mL	0.5569 mL	1.1139 mL	5.5694 mL
20 mM	0.0557 mL	0.2785 mL	0.5569 mL	2.7847 mL
50 mM	0.0223 mL	0.1114 mL	0.2228 mL	1.1139 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0111 mL	0.0557 mL	0.1114 mL	0.5569 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc