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JAK1-IN-8

Name: JAK1-IN-8
Brand: TargetMol
SKU: T35899
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T35899Cas No. 1973485-18-5

Alias JAK1-IN-8

JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50<500 nM).

JAK1-IN-8

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Purity: 98.4%

Catalog No. T35899Alias JAK1-IN-8Cas No. 1973485-18-5

JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50<500 nM).

Pack Size	Price	Availability
5 mg	$39	In Stock
10 mg	$72	In Stock
25 mg	$147	In Stock
50 mg	$263	In Stock
100 mg	$447	In Stock
200 mg	$598	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock

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Batch Information

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Purity:98.4%

Resource Download

COA HNMR LCMS LCMS

Product Introduction

Bioactivity

Description	JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50<500 nM).
Targets&IC50	JAK1:<500 nM, JAK3:>5000 nM, JAK2:500-1000 nM
Synonyms	JAK1-IN-8

Chemical Properties

Molecular Weight	442.51
Formula	C₂₂H₂₃FN₄O₃S
Cas No.	1973485-18-5
Smiles	Fc1cc(ccc1CN1CCS(=O)(=O)CC1)-c1cccc2nc(NC(=O)C3CC3)cn12

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 112.5 mg/mL (254.2 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2598 mL	11.2992 mL	22.5984 mL	112.9918 mL
5 mM	0.4520 mL	2.2598 mL	4.5197 mL	22.5984 mL
10 mM	0.2260 mL	1.1299 mL	2.2598 mL	11.2992 mL
20 mM	0.1130 mL	0.5650 mL	1.1299 mL	5.6496 mL
50 mM	0.0452 mL	0.2260 mL	0.4520 mL	2.2598 mL
100 mM	0.0226 mL	0.1130 mL	0.2260 mL	1.1299 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc