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Dihydrocurcumin
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Catalog No. T3S1701Cas No. 76474-56-1
Dihydrocurcumin is the main metabolite of curcumin, which can reduce fat accumulation and oxidative stress response. Dihydrocurcumin can regulate the mRNA and protein expression levels of SREBP-1C, PNPLA3 and PPARα, increase the protein expression levels of pAKT and PI3K, and reduce the intracellular NO and ROS contents through Nrf2 signaling pathway.
Dihydrocurcumin
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Purity: 98.47%
Catalog No. T3S1701Cas No. 76474-56-1
Dihydrocurcumin is the main metabolite of curcumin, which can reduce fat accumulation and oxidative stress response. Dihydrocurcumin can regulate the mRNA and protein expression levels of SREBP-1C, PNPLA3 and PPARα, increase the protein expression levels of pAKT and PI3K, and reduce the intracellular NO and ROS contents through Nrf2 signaling pathway.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $128 | - | In Stock | |
| 5 mg | $228 | In Stock | In Stock | |
| 10 mg | $378 | - | In Stock | |
| 25 mg | Preferential | - | In Stock | |
| 50 mg | Preferential | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:98.47%
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Dihydrocurcumin is the main metabolite of curcumin, which can reduce fat accumulation and oxidative stress response. Dihydrocurcumin can regulate the mRNA and protein expression levels of SREBP-1C, PNPLA3 and PPARα, increase the protein expression levels of pAKT and PI3K, and reduce the intracellular NO and ROS contents through Nrf2 signaling pathway. |
| In vitro | Colon bacteria may mediate the transformation of curcumin, but this metabolism has not been well studied. Methods AND RESULTS: The metabolism of curcumin to Escherichia Ferguson (ATCC 35469) and two strains of Escherichia coli (ATCC 8739 and DH10B) was studied in modified colonic bacteria (mMCB) medium of porcine cecal fluid with or without medication. LC-MS analysis showed that after fermentation for 36 h, the conversion rate of curcumin was 16-37%, the conversion rate of demethoxycurcumin (DMC) was 6-16%, the conversion rate of dimethoxycurcumin (bi-DMC) was 7-15%, and the conversion rate of dimethoxycurcumin (bi-DMC) was 7-15%. The amount of curcumin degradation varies with different strains and medium. Three metabolites (dihydrocurcumin (DHC), tetrahydrocurcumin (THC) and ferulic acid (FA)) were identified in the fermentation culture of all strains. In addition, a compound of m/z [M-H](-) 470 was found and identified as curcumin-adduct (curcumin-L-cysteine) by precise mass FT-ICR-MS. Conclusion: This study provides a new scheme for the bacterial metabolism of curcumin[1]. |
| Molecular Weight | 370.4 |
| Formula | C21H22O6 |
| Cas No. | 76474-56-1 |
| Smiles | COc1cc(CCC(=O)\C=C(/O)\C=C\c2ccc(O)c(OC)c2)ccc1O |
| Relative Density. | 1.277g/cm3 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 22.5 mg/mL (60.75 mM), Sonication and heating to 60℃ are recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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