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Scutellarein

Name: Scutellarein
Brand: TargetMol
SKU: T3319
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3319Cas No. 529-53-3

Alias 6-Hydroxyapigenin, 4',5,6,7-Tetrahydroxyflavone

Scutellarein (6-Hydroxyapigenin) reduces inflammatory responses by inhibiting Src kinase activity.

Scutellarein

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Purity: 99.63%

Catalog No. T3319Alias 6-Hydroxyapigenin, 4',5,6,7-TetrahydroxyflavoneCas No. 529-53-3

Scutellarein (6-Hydroxyapigenin) reduces inflammatory responses by inhibiting Src kinase activity.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$34	In Stock	In Stock
5 mg	$51	In Stock	In Stock
10 mg	$73	In Stock	In Stock
25 mg	$117	In Stock	In Stock
50 mg	$170	In Stock	In Stock
100 mg	$253	In Stock	In Stock
200 mg	$375	-	In Stock
1 mL x 10 mM (in DMSO)	$57	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.63%

Color:Yellow

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COA HNMR LCMS

Product Introduction

Scutellarein AI Summary

Scutellarein exhibits diverse bioactivities across various biological targets. It demonstrates binding affinity towards the benzodiazepine site in the GABAA receptor with a Ki value of 12022.64 nM, and acts as an inhibitor of cow milk xanthine oxidase with an IC50 value of 12600.0 nM and an inhibition rate of 67.3% at 50 µg/mL. It also inhibits human salivary alpha-amylase, showing an IC50 value of 9640.0 nM and 98.4% inhibition. Additionally, it has antihistaminic activity in rat RBL2H3 cells with an IC50 value of 67200.0 nM. Scutellarein shows selectivity for Trypanosoma cruzi trans-sialidase with an IC50 value of 50000.0 nM over human Neu2, with the latter having an IC50 value of 55000.0 nM. For Influenza A PR/8/34 H1N1 virus neuraminidase, it has an IC50 value of 14.48 µg/mL. The compound possesses antioxidant properties, indicated by various assays including DPPH radical scavenging (IC50 = 24040.0 nM), ABTS radical scavenging, and ferrous ion chelating activity. It also impacts drug-metabolizing enzymes, inhibiting CYP1A1 and CYP1B1 with Ki values of 1640.0 nM and 220.0 nM respectively. Scutellarein inhibits the SARS coronavirus nsP13 ATP hydrolysis with an IC50 of 860.0 nM and greater than 90% inhibition at 10 µM. It exhibits inhibitory actions against Avian myeloblastosis virus reverse transcriptase (99.4%) and inhibits recombinant FLT3 with an IC50 value over 10000.0 nM. It also shows moderate bioactivity against human IDH1 and its R132H mutant, and acts as an inhibitor of human recombinant GRK6 (IC50 = 6610.0 nM) and human liver FBP1 (IC50 = 38200.0 nM). The compound demonstrates effects on various phosphatases including PTP-sigma and SHP1 (inhibition of 90.8% and 93.2% respectively), but low inhibition of PTP-alpha (< 0.1%). Further activities include its role as an agonist at mouse PPARgamma receptor with an EC50 of 16400.0 nM and fold activation of 3.4. It acts as an anticoagulant in rabbit plasma, prolonging thrombin time, activated partial thromboplastin time, and prothrombin time while decreasing fibrinogen levels. Scutellarein is soluble in water (14.4 µg/mL), stable in buffer (half-life of 5.5 hours), and has moderate lipophilicity (LogP of 0.96). Overall, Scutellarein's multifaceted bioactivities suggest potential utility across various pharmaceutical domains, including enzymatic inhibition, receptor modulation, and antioxidative and anticoagulant strategies..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Scutellarein (6-Hydroxyapigenin) reduces inflammatory responses by inhibiting Src kinase activity.
Synonyms	6-Hydroxyapigenin, 4',5,6,7-Tetrahydroxyflavone

Chemical Properties

Molecular Weight	286.24
Formula	C₁₅H₁₀O₆
Cas No.	529-53-3
Smiles	Oc1ccc(cc1)-c1cc(=O)c2c(O)c(O)c(O)cc2o1
Relative Density.	1.654g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (174.68 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.99 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4936 mL	17.4679 mL	34.9357 mL	174.6786 mL
5 mM	0.6987 mL	3.4936 mL	6.9871 mL	34.9357 mL
10 mM	0.3494 mL	1.7468 mL	3.4936 mL	17.4679 mL
20 mM	0.1747 mL	0.8734 mL	1.7468 mL	8.7339 mL
50 mM	0.0699 mL	0.3494 mL	0.6987 mL	3.4936 mL
100 mM	0.0349 mL	0.1747 mL	0.3494 mL	1.7468 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc