Shopping Cart

Your shopping cart is currently empty

Sodium taurocholate

Name: Sodium taurocholate
Brand: TargetMol
SKU: TWA2417
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. TWA2417Cas No. 145-42-6

Alias Taurocholate Sodium

Sodium taurocholate is a biologically active compound that can inhibit bile duct injury induced by hepatic artery ligation by upregulating VEGF-A expression. It also exhibits immunomodulatory effects and can be used to induce pancreatitis models.

Sodium taurocholate

Copy Product Info

😃Good

Purity: 99.64%

Catalog No. TWA2417Alias Taurocholate SodiumCas No. 145-42-6

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$50	In Stock	In Stock
1 g	$64	In Stock	In Stock
5 g	$105	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.64%

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Sodium taurocholate AI Summary

Sodium taurocholate exhibits multifaceted bioactivities, notably as an inhibitor of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells, where it demonstrated a 19.1% inhibition at a concentration of 100 µM as observed via confocal microscopy. It also shows significant antiplasmodial activity against various strains of Plasmodium falciparum with IC50 values ranging from 2511.89 nM to 3981.07 nM after 72 hours, as determined by the SYBR green assay, suggesting its potential to inhibit malaria parasite growth. Furthermore, Sodium taurocholate aids in the restoration of human BSEP E297G mutant trafficking to the cell membrane in MDCK2 cells co-expressing NTCP, evidenced by a 105.0% activity in [3H]taurocholate accumulation assays, indicating its promise in correcting protein trafficking defects..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Sodium taurocholate is a biologically active compound that can inhibit bile duct injury induced by hepatic artery ligation by upregulating VEGF-A expression. It also exhibits immunomodulatory effects and can be used to induce pancreatitis models.
Synonyms	Taurocholate Sodium

Chemical Properties

Molecular Weight	537.69
Formula	C₂₆H₄₄NO₇S.Na
Cas No.	145-42-6
Smiles	[Na+].C[C@H](CCC(=O)NCCS([O-])(=O)=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)CC4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C
Relative Density.	1.177 g/cm3 at 22.5℃

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 53.76 mg/mL (99.98 mM), Sonication is recommended.

DMSO: 176.4 mg/mL (328.07 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (4.65 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8598 mL	9.2990 mL	18.5981 mL	92.9904 mL
5 mM	0.3720 mL	1.8598 mL	3.7196 mL	18.5981 mL
10 mM	0.1860 mL	0.9299 mL	1.8598 mL	9.2990 mL
20 mM	0.0930 mL	0.4650 mL	0.9299 mL	4.6495 mL
50 mM	0.0372 mL	0.1860 mL	0.3720 mL	1.8598 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0186 mL	0.0930 mL	0.1860 mL	0.9299 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc