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W-7 hydrochloride

🥰Excellent
Catalog No. T20792Cas No. 61714-27-0
Alias W-7 HCl, W7 HCl, W 7 HCl

W-7 hydrochloride (W-7 HCl), a calmodulin antagonist, inhibits Ca2+-calmodulin-dependent myosin light chain kinase and phosphodiesterase, W-7 hydrochloride induces apoptosis and has antitumor activity.

W-7 hydrochloride
Other Forms of W-7 hydrochloride:
W 7T3509565595-90-6
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W-7 hydrochloride

🥰Excellent
Purity: 99.63%
Catalog No. T20792Alias W-7 HCl, W7 HCl, W 7 HClCas No. 61714-27-0
W-7 hydrochloride (W-7 HCl), a calmodulin antagonist, inhibits Ca2+-calmodulin-dependent myosin light chain kinase and phosphodiesterase, W-7 hydrochloride induces apoptosis and has antitumor activity.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$30In StockIn Stock
25 mg$54In StockIn Stock
50 mgPreferentialIn StockIn Stock
1 mL x 10 mM (in DMSO)$29In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.63%
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COA LCMS HNMR HPLC

Product Introduction

Bioactivity
Description
W-7 hydrochloride (W-7 HCl), a calmodulin antagonist, inhibits Ca2+-calmodulin-dependent myosin light chain kinase and phosphodiesterase, W-7 hydrochloride induces apoptosis and has antitumor activity.
Targets&IC50
PDE:28 μM (IC50), Myosin light chain kinase:51 µM (IC50)
SynonymsW-7 HCl, W7 HCl, W 7 HCl
Chemical Properties
Molecular Weight377.32
FormulaC16H22Cl2N2O2S
Cas No.61714-27-0
SmilesC1=CC2=C(C=CC=C2Cl)C(=C1)S(=O)(=O)NCCCCCCN.Cl
Relative Density.no data available
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 250 mg/mL (662.55 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (13.25 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6503 mL13.2514 mL26.5027 mL132.5135 mL
5 mM0.5301 mL2.6503 mL5.3005 mL26.5027 mL
10 mM0.2650 mL1.3251 mL2.6503 mL13.2514 mL
20 mM0.1325 mL0.6626 mL1.3251 mL6.6257 mL
50 mM0.0530 mL0.2650 mL0.5301 mL2.6503 mL
100 mM0.0265 mL0.1325 mL0.2650 mL1.3251 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

W-7 HydrochlorideW7 hydrochlorideW7 HydrochlorideW-7W 7 HydrochlorideW 7 hydrochlorideW 7Phosphodiesterase (PDE)phosphodiesterasephosphateMyosinlightInhibitorinhibitchainCaMKCaMcalmodulinCalmodulinCalcium-modulated proteinCa2+Apoptosisapoptosisantitumoranti-proliferation
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