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GNE-900

Catalog No. T71259 CAS 1200126-26-6

Synonyms: GNE900, GNE 900

GNE-900 is an ATP-competitive ChK1 inhibitor with selective and oral activity.GNE-900 inhibits ChKl and ChK2 with IC50 values of 0.0011 and 1.5 µM, respectively.GNE-900 enhances DNA damage and induces apoptosis. GNE-900 has antitumor activity.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

GNE-900, CAS 1200126-26-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 67.00
5 mg	In stock	$ 163.00
10 mg	In stock	$ 289.00
25 mg	In stock	$ 487.00
50 mg	In stock	$ 696.00
100 mg	In stock	$ 987.00

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Purity: 97.18%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	GNE-900 is an ATP-competitive ChK1 inhibitor with selective and oral activity.GNE-900 inhibits ChKl and ChK2 with IC50 values of 0.0011 and 1.5 µM, respectively.GNE-900 enhances DNA damage and induces apoptosis. GNE-900 has antitumor activity.
Targets&IC50	Chk1:0.0011 μM, Chk2:1.5 μM
In vitro	GNE-900 (1 µM; 1-48 h; HT-29 cells) induces apoptosis and increases expression of cleaved PARP when combined with gemcitabine (50 nM) in HT-29 cells.[1]
In vivo	GNE-900 (2.5-40 mg/kg; p.o.; once; Sprague-Dawley rats) combined with gemcitabine (120 mg/kg) reduced tumor volume and increased DNA damage and γ-H2AX expression levels in rats.[1]

Synonyms	GNE900, GNE 900
Molecular Weight	367.45
Formula	C23H21N5
CAS No.	1200126-26-6

Storage

store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Blackwood E, et al. Combination drug scheduling defines a "window of opportunity" for chemopotentiation of gemcitabine by an orally bioavailable, selective ChK1 inhibitor, GNE-900. Mol Cancer Ther. 2013 Oct;12(10):1968-80.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Inhibitor Library Bioactive Compound Library Anti-Cancer Compound Library Kinase Inhibitor Library Bioactive Compounds Library Max

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GNE-900 1200126-26-6 Apoptosis Cell Cycle/Checkpoint Chk GNE900 GNE 900 Omeprazole acid inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.