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Lalistat 2

Name: Lalistat 2
Brand: TargetMol
SKU: T41160
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T41160Cas No. 1234569-09-5

Lalistat 2 is a selective inhibitor of lysosomal acid lipase with IC50 of 152 nM and exhibits no inhibition of human pancreatic lipase or bovine milk lipoprotein lipase (up to 10 μM).

Lalistat 2

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Purity: 99.84%

Catalog No. T41160Cas No. 1234569-09-5

Lalistat 2 is a selective inhibitor of lysosomal acid lipase with IC50 of 152 nM and exhibits no inhibition of human pancreatic lipase or bovine milk lipoprotein lipase (up to 10 μM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$38	In Stock	In Stock
5 mg	$89	In Stock	In Stock
10 mg	$139	In Stock	In Stock
25 mg	$275	In Stock	In Stock
50 mg	$513	-	In Stock
100 mg	$747	-	In Stock
500 mg	$1,560	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$97	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.84%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Lalistat 2 AI Summary

Lalistat 2 demonstrates significant bioactivity as an inhibitor of human Lysosomal Acid Lipase (LAL) and Mycobacterium tuberculosis H37Rv lipase. For human LAL, it reduces the enzyme decarbamoylation rate constant at a concentration of 10 µM after 30 minutes, with an activity rate of 0.001/min as measured by a fluorescence assay, and has an IC50 value of 152.0 nM under the same conditions. In the context of Mycobacterium tuberculosis H37Rv, Lalistat 2 shows a Minimum Inhibitory Concentration (MIC) of 25,000 nM, suggesting its efficacy in bacterial growth inhibition. The compound also demonstrates a ratio of MIC in the absence to presence of vancomycin of 4.0, indicating potential synergistic effects, and achieves a 55.0% growth inhibition in infected human monocyte-derived macrophages, underscoring its ability to inhibit bacterial proliferation within host cells..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Lalistat 2 is a selective inhibitor of lysosomal acid lipase with IC50 of 152 nM and exhibits no inhibition of human pancreatic lipase or bovine milk lipoprotein lipase (up to 10 μM).

Chemical Properties

Molecular Weight	296.39
Formula	C₁₃H₂₀N₄O₂S
Cas No.	1234569-09-5
Smiles	O=C(Oc1nsnc1N1CCCCC1)N1CCCCC1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (843.48 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.75 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3739 mL	16.8697 mL	33.7393 mL	168.6966 mL
5 mM	0.6748 mL	3.3739 mL	6.7479 mL	33.7393 mL
10 mM	0.3374 mL	1.6870 mL	3.3739 mL	16.8697 mL
20 mM	0.1687 mL	0.8435 mL	1.6870 mL	8.4348 mL
50 mM	0.0675 mL	0.3374 mL	0.6748 mL	3.3739 mL
100 mM	0.0337 mL	0.1687 mL	0.3374 mL	1.6870 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc