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CXCR2-IN-2

Catalog No. T36923 CAS 1838123-21-9

CXCR2-IN-2 is a selective, brain penetrant, and orally bioavailable CXCR2 antagonist (IC50=5.2 nM/1 nM in β-arrestin assay/CXCR2 Tango assay, respectively). CXCR2-IN-2 displays ~730-fold selectivity over CXCR1 and >1900-fold selectivity over all other chemokine receptors. CXCR2-IN-2 inhibits human whole blood Gro-α induced CD11b expression with an IC50 of 0.04 μM[1].

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CXCR2-IN-2, CAS 1838123-21-9

Pack Size	Availability	Price/USD
5 mg	8-10 weeks	$ 332.00
50 mg	8-10 weeks	$ 1,820.00
100 mg	8-10 weeks	$ 2,820.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CXCR2-IN-2 is a selective, brain penetrant, and orally bioavailable CXCR2 antagonist (IC50=5.2 nM/1 nM in β-arrestin assay/CXCR2 Tango assay, respectively). CXCR2-IN-2 displays ~730-fold selectivity over CXCR1 and >1900-fold selectivity over all other chemokine receptors. CXCR2-IN-2 inhibits human whole blood Gro-α induced CD11b expression with an IC50 of 0.04 μM[1].
Targets&IC50	CXCR1:3.8 μM (IC50), CXCR2:5.2 nM (IC50)
In vivo	CXCR2-IN-2 (compound 68) (1-10 mg/kg; p.o.; twice daily for 3 days) dose-dependently reduces neutrophil infiltration in vivo in rat and mouse air pouch models[1].

Molecular Weight	414.9
Formula	C18H23ClN2O5S
CAS No.	1838123-21-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 240 mg/mL (578.45 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Lu H, et al. Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists. J Med Chem. 2018;61(6):2518-2532.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CXCR2-IN-2 1838123-21-9 CXCR2IN2 CXCR2 IN 2 CXCR-2-IN-2 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.