Powder: -20°C for 3 years | In solvent: -80°C for 2 years
CXCR2-IN-2 is a selective, brain penetrant, and orally bioavailable CXCR2 antagonist (IC50=5.2 nM/1 nM in β-arrestin assay/CXCR2 Tango assay, respectively). CXCR2-IN-2 displays ~730-fold selectivity over CXCR1 and >1900-fold selectivity over all other chemokine receptors. CXCR2-IN-2 inhibits human whole blood Gro-α induced CD11b expression with an IC50 of 0.04 μM[1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | 8-10 weeks | $ 332.00 | |
50 mg | 8-10 weeks | $ 1,820.00 | |
100 mg | 8-10 weeks | $ 2,820.00 |
Description | CXCR2-IN-2 is a selective, brain penetrant, and orally bioavailable CXCR2 antagonist (IC50=5.2 nM/1 nM in β-arrestin assay/CXCR2 Tango assay, respectively). CXCR2-IN-2 displays ~730-fold selectivity over CXCR1 and >1900-fold selectivity over all other chemokine receptors. CXCR2-IN-2 inhibits human whole blood Gro-α induced CD11b expression with an IC50 of 0.04 μM[1]. |
Targets&IC50 | CXCR1:3.8 μM (IC50), CXCR2:5.2 nM (IC50) |
In vivo | CXCR2-IN-2 (compound 68) (1-10 mg/kg; p.o.; twice daily for 3 days) dose-dependently reduces neutrophil infiltration in vivo in rat and mouse air pouch models[1]. |
Molecular Weight | 414.9 |
Formula | C18H23ClN2O5S |
CAS No. | 1838123-21-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
DMSO: 240 mg/mL (578.45 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CXCR2-IN-2 1838123-21-9 CXCR2IN2 CXCR2 IN 2 CXCR-2-IN-2 inhibitor inhibit