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6-Maleimidocapronic acid

Name: 6-Maleimidocapronic acid
Brand: TargetMol
SKU: T14060
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14060Cas No. 55750-53-3

6-Maleimidocapronic acid, an alkyl chain-based PROTAC linker, is utilized in the synthesis of PROTACs (proteolysis-targeting chimeras).

6-Maleimidocapronic acid

🥰Excellent

Catalog No. T14060Cas No. 55750-53-3

6-Maleimidocapronic acid, an alkyl chain-based PROTAC linker, is utilized in the synthesis of PROTACs (proteolysis-targeting chimeras).

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Questions

Batch Information

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Purity:≥98%

Resource Download

COA HNMR

Product Introduction

Bioactivity

Description	6-Maleimidocapronic acid, an alkyl chain-based PROTAC linker, is utilized in the synthesis of PROTACs (proteolysis-targeting chimeras).
In vitro	PROTACs consist of two distinct ligands linked together; one targets an E3 ubiquitin ligase, and the other binds to the target protein. They utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Chemical Properties

Molecular Weight	211.21
Formula	C₁₀H₁₃NO₄
Cas No.	55750-53-3
Smiles	C(CCCCC(O)=O)N1C(=O)C=CC1=O
Relative Density.	1.285 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 190 mg/mL (899.58 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.7346 mL	23.6731 mL	47.3462 mL	236.7312 mL
5 mM	0.9469 mL	4.7346 mL	9.4692 mL	47.3462 mL
10 mM	0.4735 mL	2.3673 mL	4.7346 mL	23.6731 mL
20 mM	0.2367 mL	1.1837 mL	2.3673 mL	11.8366 mL
50 mM	0.0947 mL	0.4735 mL	0.9469 mL	4.7346 mL
100 mM	0.0473 mL	0.2367 mL	0.4735 mL	2.3673 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc