GSK3532795

Name: GSK3532795
Brand: TargetMol
SKU: T11494
Rating: 4.5 (1 reviews)

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Catalog No. T11494Cas No. 1392312-45-6

Alias BMS-955176

GSK3532795 is a potent, orally active, second-generation HIV-1 maturation inhibitor (EC50s: 10.2, 1.9, 2.7, and 13 nM for HIV-1 WT(human serum), HIV-1 WT, HIV-1 V370A, and HIV-1 ΔV370).

GSK3532795

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Catalog No. T11494Alias BMS-955176Cas No. 1392312-45-6

GSK3532795 is a potent, orally active, second-generation HIV-1 maturation inhibitor (EC50s: 10.2, 1.9, 2.7, and 13 nM for HIV-1 WT(human serum), HIV-1 WT, HIV-1 V370A, and HIV-1 ΔV370).

Pack Size	Price	Availability
25 mg	$1,970	8-10 weeks
50 mg	$2,580	8-10 weeks
100 mg	$3,400	8-10 weeks

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Product Introduction

Bioactivity

Description	GSK3532795 is a potent, orally active, second-generation HIV-1 maturation inhibitor (EC50s: 10.2, 1.9, 2.7, and 13 nM for HIV-1 WT(human serum), HIV-1 WT, HIV-1 V370A, and HIV-1 ΔV370).
Targets&IC50	HIV-1 (V370): 13 nM , HIV-1 (V370A): 2.7 nM , HIV-1 (WT): 10.2 nM , HIV-1 (WT):(EC50)1.9 nM
In vitro	GSK3532795 demonstrates binding affinities, expressed as equilibrium dissociation constants (Kds), of 3.2 ± 0.6 nM for HIV wild-type (WT), 4.3 ± 2.0 nM for the HIV V362I variant, 6.5 ± 2.2 nM for the HIV V370A variant, and 33.6 ± 5.9 nM for the HIV ΔV370 variant, indicating its effectiveness in targeting different forms of HIV.
Synonyms	BMS-955176

Chemical Properties

Molecular Weight	691.02
Formula	C₄₂H₆₂N₂O₄S
Cas No.	1392312-45-6
Relative Density.	1.19 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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