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Iodixanol

Name: Iodixanol
Brand: TargetMol
SKU: T1196
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1196Cas No. 92339-11-2

Alias Visipaque, Acupaque

Iodixanol (Visipaque) is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography.

Iodixanol

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Purity: 99.68%

Catalog No. T1196Alias Visipaque, AcupaqueCas No. 92339-11-2

Iodixanol (Visipaque) is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$31	In Stock	In Stock
25 mg	$64	In Stock	In Stock
50 mg	$98	In Stock	In Stock
100 mg	$156	In Stock	In Stock
500 mg	$413	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$65	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.68%

Appearance:Solid

Color:White

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COA LCMS

Product Introduction

Iodixanol AI Summary

Iodixanol exhibits significant bioactivity related to liver enzyme activity, demonstrated by increases in alkaline phosphatase, serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), lactate dehydrogenase (LDH), and gamma-glutamyl transferase (GGT). Despite these enzyme changes, Iodixanol shows no hepatic side effects based on the Drug Induced Liver Injury Prediction System (DILIps) training set, including liver function abnormalities and liver diseases. Moreover, it demonstrates antiviral activity by inhibiting Ebola virus entry with AC50 values between 7.943 µM and 22.39 µM and cytotoxicity in Ebola-related assays. It also exhibits a moderate toxicity level towards cell viability in VERO-6 cells infected with SARS-CoV-2, with an IC50 value greater than 19952.62 nM. Additional bioactivity includes inhibition of human HDAC6 enzyme activity, showing inhibition percentages of 3.77% and 1.47% using commercial and custom peptide substrates, respectively. Notably, Iodixanol has a very low inhibition index for SARS-CoV-2 in Vero E6 cells, showcasing minimal activity in this context..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Iodixanol (Visipaque) is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography.
Synonyms	Visipaque, Acupaque

Chemical Properties

Molecular Weight	1550.18
Formula	C₃₅H₄₄I₆N₆O₁₅
Cas No.	92339-11-2
Smiles	CC(=O)N(CC(O)CN(C(C)=O)c1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I)c1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I
Relative Density.	1.266 ±0.003 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 32.55 mg/mL (21 mM), Sonication and heating are recommended.

DMSO: 255 mg/mL (164.5 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (3.23 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.6451 mL	3.2254 mL	6.4509 mL	32.2543 mL
5 mM	0.1290 mL	0.6451 mL	1.2902 mL	6.4509 mL
10 mM	0.0645 mL	0.3225 mL	0.6451 mL	3.2254 mL
20 mM	0.0323 mL	0.1613 mL	0.3225 mL	1.6127 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0129 mL	0.0645 mL	0.1290 mL	0.6451 mL
100 mM	0.0065 mL	0.0323 mL	0.0645 mL	0.3225 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc