Shopping Cart

Your shopping cart is currently empty

Resiniferatoxin

Name: Resiniferatoxin
Brand: TargetMol
SKU: T34295
Price: 456 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Hot

Catalog No. T34295Cas No. 57444-62-9

Alias RTX, [3H]resiniferatoxin

Resiniferatoxin ((+)-Resiniferatoxin) is a highly potent synthetic TRPV1 agonist that inhibits the production of Th1 cytokines and has anti-inflammatory activity, reducing serum levels of IL-12, INF-γ, IL-1β, TNF-α, NO, and PGE.

Resiniferatoxin

Copy Product Info

😃Good

Hot

Purity: 99.34%

Catalog No. T34295Alias RTX, [3H]resiniferatoxinCas No. 57444-62-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$456	-	In Stock
5 mg	$1,130	In Stock	In Stock
10 mg	$1,530	6-8 weeks	6-8 weeks
1 mL x 10 mM (in DMSO)	$1,380	6-8 weeks	6-8 weeks

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.34%

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Resiniferatoxin ((+)-Resiniferatoxin) is a highly potent synthetic TRPV1 agonist that inhibits the production of Th1 cytokines and has anti-inflammatory activity, reducing serum levels of IL-12, INF-γ, IL-1β, TNF-α, NO, and PGE.
In vitro	METHODS: RAW264.7 cells were treated with LPS (100 ng/ml) and IFN-γ (3 ng ml−1) and then treated with Resiniferatoxin ((+)-Resiniferatoxin) (0.01, 0.1, 1, 10.24 h). The culture medium was collected for NO determination, and the cell lysates were subjected to SDS-PAGE to measure and quantify iNOS or COX-2 immunoreactivity. RESULTS At a concentration of 10 μM, Resiniferatoxin ((+)-Resiniferatoxin) inhibited LPS-induced NO production by 67±10% and 52±6%, respectively, and failed to affect LPS-induced COX-2 and PGE2 responses. [3]
In vivo	METHODS: Resiniferatoxin ((+)-Resiniferatoxin) (2 μg/10 μl) was injected intrathecally into the T2/T3 space of mice. Cardiac sympathetic nerve activity (CSNA) and cardiac electrophysiology were assessed two weeks later. RESULTS Intrathecal injection of Resiniferatoxin ((+)-Resiniferatoxin) significantly and selectively eliminated the expression of dorsal horn afferent markers (TRPV1 and calcitonin gene-related peptide) and reduced overactive CSNA. Electrophysiological studies have shown that intrathecal administration of Resiniferatoxin ((+)-Resiniferatoxin) can significantly reverse the prolongation of action potential duration (APD) and APD alternating hormones and reduce the inducibility of ventricular arrhythmias. [4]
Synonyms	RTX, [3H]resiniferatoxin

Chemical Properties

Molecular Weight	628.71
Formula	C₃₇H₄₀O₉
Cas No.	57444-62-9
Smiles	C[C@H]1[C@]23[C@]([C@@]4([C@](C(C)=C)(C1)O[C@](CC5=CC=CC=C5)(O2)O4)[H])(C=C(COC(CC6=CC(OC)=C(O)C=C6)=O)C[C@@]7(O)[C@]3(C=C(C)C7=O)[H])[H]
Relative Density.	1.35g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 32 mg/mL (50.9 mM)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (1.59 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5906 mL	7.9528 mL	15.9056 mL	79.5279 mL
5 mM	0.3181 mL	1.5906 mL	3.1811 mL	15.9056 mL
10 mM	0.1591 mL	0.7953 mL	1.5906 mL	7.9528 mL
20 mM	0.0795 mL	0.3976 mL	0.7953 mL	3.9764 mL
50 mM	0.0318 mL	0.1591 mL	0.3181 mL	1.5906 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc