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Notoginsenoside R2

Name: Notoginsenoside R2
Brand: TargetMol
SKU: T6S1587
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6S1587Cas No. 80418-25-3

Alias Ginsenoside Ng-R2, 20(S)-Notoginsenoside R2

Notoginsenoside R2 (20(S)-Notoginsenoside R2) has neuroprotection against 6-OHDA-induced neurotoxicity, is associated with Notoginsenoside R2-mediated P90RSK and Nrf2 activation through MEK1/2-ERK1/2 pathways.

Notoginsenoside R2

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Purity: 99.92%

Catalog No. T6S1587Alias Ginsenoside Ng-R2, 20(S)-Notoginsenoside R2Cas No. 80418-25-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$33	In Stock	In Stock
5 mg	$70	In Stock	In Stock
10 mg	$100	In Stock	In Stock
25 mg	$163	In Stock	In Stock
50 mg	$239	In Stock	In Stock
100 mg	$356	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$120	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.92%

Color:White

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COA LCMS HNMR

Product Introduction

Notoginsenoside R2 AI Summary

Notoginsenoside R2 exhibits significant bioactivity as an inhibitor of cell proliferation in both human U251 and rat C6 cells. In human U251 cells, it demonstrated a cell viability inhibition activity of 107.8% at a concentration of 100 µM after 72 hours, as assessed by the sulforhodamine B assay. Additionally, in rat C6 cells, the compound inhibited cell viability by 59.31% under identical conditions..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Notoginsenoside R2 (20(S)-Notoginsenoside R2) has neuroprotection against 6-OHDA-induced neurotoxicity, is associated with Notoginsenoside R2-mediated P90RSK and Nrf2 activation through MEK1/2-ERK1/2 pathways.
Synonyms	Ginsenoside Ng-R2, 20(S)-Notoginsenoside R2

Chemical Properties

Molecular Weight	770.99
Formula	C₄₁H₇₀O₁₃
Cas No.	80418-25-3
Smiles	[H][C@@]1(CC[C@]2(C)[C@]1([H])[C@H](O)C[C@]1([H])[C@@]3(C)CC[C@H](O)C(C)(C)[C@]3([H])[C@H](C[C@@]21C)O[C@]1([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O[C@]1([H])OC[C@@H](O)[C@H](O)[C@H]1O)[C@@](C)(O)CCC=C(C)C
Relative Density.	1.314g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (32.43 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.59 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2970 mL	6.4852 mL	12.9703 mL	64.8517 mL
5 mM	0.2594 mL	1.2970 mL	2.5941 mL	12.9703 mL
10 mM	0.1297 mL	0.6485 mL	1.2970 mL	6.4852 mL
20 mM	0.0649 mL	0.3243 mL	0.6485 mL	3.2426 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc