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GSK-843

Name: GSK-843
Brand: TargetMol
SKU: T11474
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11474Cas No. 1601496-05-2

Alias GSK'843

GSK-843 (GSK'843) is a selective and potent RIP3 inhibitor with an IC50 value of 8.6 nM for the structural domain of RIP3 kinase. It has potential analgesic activity, inhibits the expression of RIP3 and NLRP3 in the SDH of CFA mice, and can be used as adjunctive therapy for treating inflammation.

GSK-843

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Purity: 99.28%

Catalog No. T11474Alias GSK'843Cas No. 1601496-05-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$41	-	In Stock
5 mg	$91	-	In Stock
10 mg	$149	-	In Stock
25 mg	$332	-	In Stock
50 mg	$531	-	In Stock
100 mg	$846	-	In Stock
1 mL x 10 mM (in DMSO)	$98	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.28%

Appearance:Solid

Color:Yellow to Orange

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	GSK-843 (GSK'843) is a selective and potent RIP3 inhibitor with an IC50 value of 8.6 nM for the structural domain of RIP3 kinase. It has potential analgesic activity, inhibits the expression of RIP3 and NLRP3 in the SDH of CFA mice, and can be used as adjunctive therapy for treating inflammation.
Targets&IC50	RIP3:6.5 nM, RIP3:8.6 nM
In vitro	RIP3i GSK-843 and GSK-872 by screening conventional small molecule libraries. These compounds bound RIP3 kinase domain with high affinity (IC50 = 8.6 nM and 1.8 nM, respectively,and inhibited kinase activity (IC50 = 6.5 nM and 1.3 nM, respectively[1].
Synonyms	GSK'843

Chemical Properties

Molecular Weight	377.49
Formula	C₁₉H₁₅N₅S₂
Cas No.	1601496-05-2
Smiles	Cc1cc(-c2cnc(N)c3c(csc23)-c2ccc3scnc3c2)n(C)n1
Relative Density.	1.54 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (79.47 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.3 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6491 mL	13.2454 mL	26.4908 mL	132.4538 mL
5 mM	0.5298 mL	2.6491 mL	5.2982 mL	26.4908 mL
10 mM	0.2649 mL	1.3245 mL	2.6491 mL	13.2454 mL
20 mM	0.1325 mL	0.6623 mL	1.3245 mL	6.6227 mL
50 mM	0.0530 mL	0.2649 mL	0.5298 mL	2.6491 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc