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BMS-599626 Hydrochloride

Name: BMS-599626 Hydrochloride
Brand: TargetMol
SKU: T5390
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5390Cas No. 873837-23-1

Alias AC480 Hydrochloride

BMS-599626 Hydrochloride (AC480 Hydrochloride) is an orally bioavailable inhibitor of the HER1, HER2, and HER4 tyrosine kinases (IC50 = 22, 32, and 190 nM, respectively) with potential antineoplastic activity, inhibiting the proliferation of tumor cells that overexpress these receptors.

BMS-599626 Hydrochloride

🥰Excellent

Purity: 99.98%

Catalog No. T5390Alias AC480 HydrochlorideCas No. 873837-23-1

Pack Size	Price	Availability
1 mg	$37	In Stock
5 mg	$87	In Stock
10 mg	$133	In Stock
25 mg	$253	In Stock
50 mg	$447	In Stock
100 mg	$659	In Stock
1 mL x 10 mM (in DMSO)	$109	In Stock

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Purity:99.98%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	BMS-599626 Hydrochloride (AC480 Hydrochloride) is an orally bioavailable inhibitor of the HER1, HER2, and HER4 tyrosine kinases (IC50 = 22, 32, and 190 nM, respectively) with potential antineoplastic activity, inhibiting the proliferation of tumor cells that overexpress these receptors.
Targets&IC50	HER1:22 nM, HER2:32nM, HER4:190 nM
In vitro	BMS-599626 Hydrochloride abrogates HER1 and HER2 signaling and inhibited the proliferation of tumor cell lines that are dependent on these receptors, with IC50s in the range of 0.24 to 1 μM.In GEO cells, HER1 phosphorylation is stimulated by treatment with EGF and is inhibited by BMS-599626 Hydrochloride (IC50=0. 75 μM).There is also nearly complete inhibition of EGF-dependent MAPK (0. 8 μM) but only partial inhibition of AKT signaling.The latter likely reflects the activation of AKT by multiple upstream signals.Treatment of N87 cells with BMS-599626 Hydrochloride leads to the inhibition of HER2 (0. 38 μM), which is expressed to a high level because of gene amplification, as well as MAPK and AKT phosphorylation (0.35 μM for both) [1].
In vivo	BMS-599626 Hydrochloride given before and during irradiation improved the radioresponse of HN5 tumors in vivo [2].
Synonyms	AC480 Hydrochloride

Chemical Properties

Molecular Weight	567.01
Formula	C₂₇H₂₈ClFN₈O₃
Cas No.	873837-23-1
Smiles	Cl.Cc1c(NC(=O)OC[C@@H]2COCCN2)cn2ncnc(Nc3ccc4n(Cc5cccc(F)c5)ncc4c3)c12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90.0 mg/mL (158.7 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5.82 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7636 mL	8.8182 mL	17.6364 mL	88.1819 mL
5 mM	0.3527 mL	1.7636 mL	3.5273 mL	17.6364 mL
10 mM	0.1764 mL	0.8818 mL	1.7636 mL	8.8182 mL
20 mM	0.0882 mL	0.4409 mL	0.8818 mL	4.4091 mL
50 mM	0.0353 mL	0.1764 mL	0.3527 mL	1.7636 mL
100 mM	0.0176 mL	0.0882 mL	0.1764 mL	0.8818 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc