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Amylin (AMY3) antagonist (IC50 = 0.3 μM). Protects neuronal cells from Aβ(1-42)-induced cytotoxicity in vitro. Brain penetrant. Improves spatial memory and reduces Aβ plaque number and total area in a mouse Alzheimer's disease model.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $711 | Backorder |
Description | Amylin (AMY3) antagonist (IC50 = 0.3 μM). Protects neuronal cells from Aβ(1-42)-induced cytotoxicity in vitro. Brain penetrant. Improves spatial memory and reduces Aβ plaque number and total area in a mouse Alzheimer's disease model. |
Molecular Weight | 3009.36 |
Formula | C126H202N42O40S2 |
Relative Density. | no data available |
Sequence | H-DL-Cys(1)-DL-Leu-Gly-DL-Arg-DL-Leu-DL-Ser-DL-Gln-DL-Glu-DL-Leu-DL-His-DL-Arg-DL-Leu-DL-Gln-DL-xiThr-DL-Tyr-DL-Pro-DL-Arg-DL-xiThr-DL-Asn-DL-xiThr-Gly-DL-Ser-DL-Asn-DL-xiThr-DL-Tyr-DL-Cys(1)-NH2 |
Sequence Short | CLGRLSQELHRLQXYPRXNXGSNXYC |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Solubility Information | H2O: 1 mg/mL (0.33 mM), Sonication is recommended. |
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