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TOPRelated productsBioactivityChemical infoStorage&SolubilityCalculator

3,5-Bis(4-nitrophenoxy)benzoic acid

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Catalog No. T22678Cas No. 173550-33-9
Alias Compound W

3,5-Bis(4-nitrophenoxy)benzoic acid (Compound W) is a γ-secretase inhibitor that reduces the levels of released Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25).

3,5-Bis(4-nitrophenoxy)benzoic acid

3,5-Bis(4-nitrophenoxy)benzoic acid

🥰Excellent
Purity: 99.14%
Catalog No. T22678Alias Compound WCas No. 173550-33-9
3,5-Bis(4-nitrophenoxy)benzoic acid (Compound W) is a γ-secretase inhibitor that reduces the levels of released Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25).
Pack SizePriceAvailabilityQuantity
25 mg$41In Stock
50 mg$66In Stock
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Batch Information

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Purity:99.14%
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Product Introduction

Bioactivity
Description
3,5-Bis(4-nitrophenoxy)benzoic acid (Compound W) is a γ-secretase inhibitor that reduces the levels of released Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25).
SynonymsCompound W
Chemical Properties
Molecular Weight396.31
FormulaC19H12N2O8
Cas No.173550-33-9
SmilesOC(=O)c1cc(Oc2ccc(cc2)[N+]([O-])=O)cc(Oc2ccc(cc2)[N+]([O-])=O)c1
Relative Density.1.485g/cm3
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (126.16 mM), Sonication is recommended.
1.1eq. NaOH: < 19.81 mg/mL, Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5233 mL12.6164 mL25.2328 mL126.1639 mL
5 mM0.5047 mL2.5233 mL5.0466 mL25.2328 mL
10 mM0.2523 mL1.2616 mL2.5233 mL12.6164 mL
20 mM0.1262 mL0.6308 mL1.2616 mL6.3082 mL
50 mM0.0505 mL0.2523 mL0.5047 mL2.5233 mL
100 mM0.0252 mL0.1262 mL0.2523 mL1.2616 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

γ-secretaseγ secretasepeptidenotch-1InhibitorinhibithypothyroidismGammasecretaseGamma secretaseAβ-likeAβ423,5-Bis(4-nitrophenoxy)benzoic acid3,5Bis(4nitrophenoxy)benzoic acid3,5 Bis(4 nitrophenoxy)benzoic acid
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