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Dipyridamole

Name: Dipyridamole
Brand: TargetMol
SKU: T1618
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1618Cas No. 58-32-2

Alias Persantin, NSC-515776, Dypyridamole, Dipyudamine, Dipyridamol

Dipyridamole (Persantin) is a Platelet Aggregation Inhibitor. The physiologic effect of dipyridamole is by means of Decreased Platelet Aggregation.

Dipyridamole

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Purity: 99.84%

Catalog No. T1618Alias Persantin, NSC-515776, Dypyridamole, Dipyudamine, DipyridamolCas No. 58-32-2

Dipyridamole (Persantin) is a Platelet Aggregation Inhibitor. The physiologic effect of dipyridamole is by means of Decreased Platelet Aggregation.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$38	In Stock	In Stock
100 mg	$50	In Stock	In Stock
200 mg	$58	In Stock	In Stock
500 mg	$67	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.84%

Appearance:Solid

Color:Yellow

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COA LCMS HNMR

Product Introduction

Dipyridamole AI Summary

Dipyridamole is a multifunctional inhibitor displaying significant bioactivity across a range of targets. It primarily inhibits Phosphodiesterase 4 (PDE4) from guinea pig macrophages with an IC50 value of 500.0 nM and exhibits a range of inhibitory effects on [3H]thymidine uptake in L1210 cells, showing 80.0%-99.0% inhibition at both 1 μM and 10 μM concentrations, and retains significant activity even in the presence of alpha1-acid glycoprotein (AGP). Additionally, Dipyridamole demonstrates notable inhibitory action on several human phosphodiesterases (PDEs) with mixed potencies: it is most effective against PDE1, PDE2, PDE3, PDE4, and PDE5, with varying IC50 values. It also shows significant inhibition of nucleoside transporters, particularly human ENT1 and ENT2, with IC50 values as low as 8.1 nM for ENT1. In terms of antithrombosis, Dipyridamole has effective doses (ED50) of 142.69 μmol/kg and 72.0 mg/kg in mice. It shows mild inhibition of Batrachotoxinin [3H]BTX-B binding to sodium channels in guinea pig cerebral cortex. Furthermore, Dipyridamole has bioactivity against several malaria strains, especially Plasmodium falciparum 7G8, with IC50 values indicating substantial antiplasmodial effects. In viral studies, it has demonstrated limited antiviral activity against SARS-CoV-2. The compound exhibits transporter inhibition, demonstrating influence on P-glycoprotein, MRP, and various organic cation transporters (OCTs), and shows multidrug resistance modulation properties. It also affects hepatic and renal function markers, suggesting a moderate risk for liver toxicity. Finally, Dipyridamole indicates cytotoxicity towards certain cancer cell lines and exhibits potential in reducing cell proliferation and inducing autophagy. Overall, Dipyridamole is a potent and versatile compound with broad pharmacological profiles, making it a promising candidate for therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Dipyridamole (Persantin) is a Platelet Aggregation Inhibitor. The physiologic effect of dipyridamole is by means of Decreased Platelet Aggregation.
Synonyms	Persantin, NSC-515776, Dypyridamole, Dipyudamine, Dipyridamol

Chemical Properties

Molecular Weight	504.63
Formula	C₂₄H₄₀N₈O₄
Cas No.	58-32-2
Smiles	N(CCO)(CCO)C1=NC2=C(C(=N1)N3CCCCC3)N=C(N(CCO)CCO)N=C2N4CCCCC4
Relative Density.	1.352 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (495.41 mM), Sonication is recommended.

Ethanol: 47 mg/mL (93.14 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.54 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9816 mL	9.9082 mL	19.8165 mL	99.0825 mL
5 mM	0.3963 mL	1.9816 mL	3.9633 mL	19.8165 mL
10 mM	0.1982 mL	0.9908 mL	1.9816 mL	9.9082 mL
20 mM	0.0991 mL	0.4954 mL	0.9908 mL	4.9541 mL
50 mM	0.0396 mL	0.1982 mL	0.3963 mL	1.9816 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0198 mL	0.0991 mL	0.1982 mL	0.9908 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc