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Palmitoylisopropylamide
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Catalog No. T23119Cas No. 189939-61-5
Palmitoylisopropylamide is a selective FAAH inhibitor that inhibits [H]-AEA uptake and cell proliferation at low concentrations.
Palmitoylisopropylamide
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Catalog No. T23119Cas No. 189939-61-5
Palmitoylisopropylamide is a selective FAAH inhibitor that inhibits [H]-AEA uptake and cell proliferation at low concentrations.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $34 | In Stock | In Stock | |
| 5 mg | $53 | In Stock | In Stock | |
| 10 mg | $76 | In Stock | In Stock | |
| 25 mg | $158 | In Stock | In Stock | |
| 100 mg | $460 | In Stock | In Stock | |
| 200 mg | $647 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:>99.99%
Appearance:Solid
Color:White
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Product Introduction
Palmitoylisopropylamide AI Summary
Palmitoylisopropylamide exhibits bioactivities related to cannabinoid receptors and shows moderate inhibitory activity on the metabolism of N-arachidonoylethanolamine (AEA) in rat brain homogenates, with an IC50 value ranging from 12,882.5 nM to 14,125.38 nM. It demonstrates inhibition percentages ranging from 4.0% to 61.0% at various pH levels (6 and 9). Additionally, Palmitoylisopropylamide displays modest inhibitory effects on the specific binding of [3H]CP-55940 to human cannabinoid receptor 1 and [3H]WIN-55212-2 to human cannabinoid receptor 2 in Chinese hamster ovary cell membranes, with inhibition percentages of 25.4% and 12.3%, respectively. It also exhibits binding affinity against human Cannabinoid receptor 1 (CB1) and CB2 receptor and inhibits fatty acid amide hydrolase (FAAH) from rat brain homogenates at 10 uM and 100 uM concentrations. Moreover, it inhibits N-palmitoylethanolamine-selective acid amidase (NPAA) from rat lung homogenates at 100 uM. Palmitoylisopropylamide has an IC50 value of 13.0 nM for its potent inhibition of FAAH. Additionally, it exhibits bioactivities by inhibiting the Menin-MLL interaction in MLL-related leukemias, targeting the ERK signaling pathway, and inhibiting USP1/UAF1, with potencies of 35481.3 nM, 6309.6 nM, and 70794.6 nM, respectively..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Palmitoylisopropylamide is a selective FAAH inhibitor that inhibits [H]-AEA uptake and cell proliferation at low concentrations. |
| Molecular Weight | 297.52 |
| Formula | C19H39NO |
| Cas No. | 189939-61-5 |
| Smiles | C(CCCCCCCCCCCCC)CC(NC(C)C)=O |
| Relative Density. | 0.853g/cm3 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: Soluble |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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