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Nω-Propyl-L-arginine hydrochloride is a highly selective and competitive neuronal nitric oxide synthase inhibitor with nanomolar affinity and marked selectivity over endothelial nitric oxide synthase, making Nω-Propyl-L-arginine hydrochloride a precise pharmacological tool for investigating nitric oxide signaling, neuronal regulation, and neurovascular function.

| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $41 | - | In Stock | |
| 10 mg | $79 | - | In Stock | |
| 25 mg | $189 | - | In Stock | |
| 50 mg | $338 | - | In Stock | |
| 100 mg | $591 | - | In Stock |
| Description | Nω-Propyl-L-arginine hydrochloride is a highly selective and competitive neuronal nitric oxide synthase inhibitor with nanomolar affinity and marked selectivity over endothelial nitric oxide synthase, making Nω-Propyl-L-arginine hydrochloride a precise pharmacological tool for investigating nitric oxide signaling, neuronal regulation, and neurovascular function. |
| In vivo | In male NMRI mice, systemic administration of Nω-Propyl-L-arginine hydrochloride (20 mg/kg, i.p.) modulates behavioral responses in models of psychiatric impairment. The compound blocks behavioral deficits induced by Phencyclidine (PCP), specifically reducing PCP-induced disruptions in prepulse inhibition (PPI), a measure of sensorimotor gating. Additionally, it reduces the stimulation of locomotor activity caused by PCP. Beyond neurobehavioral models, the substance is used in renal physiology to study the regulation of renal blood flow and interstitial nitric oxide levels, helping to clarify the role of nNOS in kidney function [2][3]. |
| Synonyms | N-omega-Propyl-L-arginine hydrochloride |
| Molecular Weight | 252.74 |
| Formula | C9H21ClN4O2 |
| Cas No. | 2321366-46-3 |
| Smiles | N(CCC[C@@H](C(O)=O)N)C(NCCC)=N.Cl |
| Relative Density. | no data available |
| Color | Transparent |
| Appearance | Solid |
| Storage | store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 20 mg/mL (79.13 mM), Sonication is recommended. H2O: 20 mg/mL (79.13 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO/H2O
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