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PI3K/mTOR Inhibitor-12

Catalog No. T72374 CAS 2891692-83-2

PI3K/mTOR Inhibitor-12, a potent and selective orally active inhibitor, exhibits IC50 values of 0.06 nM for PI3Kα and 3.12 nM for mTOR, indicating significant antitumor activity with reduced liver toxicity [1].

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PI3K/mTOR Inhibitor-12 Chemical Structure

PI3K/mTOR Inhibitor-12, CAS 2891692-83-2

Pack Size	Availability	Price/USD
25 mg	8-10 weeks	$ 1,670.00
50 mg	8-10 weeks	$ 2,180.00
100 mg	8-10 weeks	$ 2,800.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

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Description	PI3K/mTOR Inhibitor-12, a potent and selective orally active inhibitor, exhibits IC50 values of 0.06 nM for PI3Kα and 3.12 nM for mTOR, indicating significant antitumor activity with reduced liver toxicity [1].
Targets&IC50	PI3Kα:0.06 nM, mTOR:3.12 nM
In vitro	PI3K/mTOR Inhibitor-12 (compound 48; 72 h) demonstrates anticancer activity by achieving half-maximal inhibitory concentration (IC50) values of 0.07 μM for PC-3 cells, 0.09 μM for HT-29 cells, and 0.54 μM for both HCT116 and LOVO cells, with 0.68 μM for HUVEC cells [1]. Additionally, at concentrations ranging from 0.25 to 1 μM over 12 to 48 hours, this compound effectively suppresses PI3K and mTOR activation in HCT116 and HT-29 cells [1].
In vivo	PI3K/mTOR Inhibitor-12 (compound 48; 20 mg/kg; orally, daily for 14 days) demonstrated effectiveness in suppressing the growth of HCT116 tumor xenografts in female BALB/c nude mice [1]. Additionally, when administered to male SD rats at 1 and 5 mg/kg intravenously and orally, this inhibitor exhibited rapid plasma clearance (1428 mL/h/kg) with a brief half-life (T 1/2) of 2.33 hours, and an area under the curve (AUC 0-∞) of 1356 h·ng/mL [1].

Molecular Weight	611.62
Formula	C27H27F2N9O4S
CAS No.	2891692-83-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PI3K/mTOR Inhibitor-12 2891692-83-2 PI3K/Akt/mTOR signaling PI3K inhibitor inhibit

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