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PI3K/mTOR Inhibitor-12

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Catalog No. T72374Cas No. 2891692-83-2

PI3K/mTOR Inhibitor-12, a potent and selective orally active inhibitor, exhibits IC50 values of 0.06 nM for PI3Kα and 3.12 nM for mTOR, indicating significant antitumor activity with reduced liver toxicity [1].

PI3K/mTOR Inhibitor-12

PI3K/mTOR Inhibitor-12

😃Good
Catalog No. T72374Cas No. 2891692-83-2
PI3K/mTOR Inhibitor-12, a potent and selective orally active inhibitor, exhibits IC50 values of 0.06 nM for PI3Kα and 3.12 nM for mTOR, indicating significant antitumor activity with reduced liver toxicity [1].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$1,6708-10 weeks8-10 weeks
50 mg$2,1808-10 weeks8-10 weeks
100 mg$2,8008-10 weeks8-10 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction

Bioactivity
Description
PI3K/mTOR Inhibitor-12, a potent and selective orally active inhibitor, exhibits IC50 values of 0.06 nM for PI3Kα and 3.12 nM for mTOR, indicating significant antitumor activity with reduced liver toxicity [1].
Targets&IC50
mTOR:3.12 nM, PI3Kα:0.06 nM
In vitro
PI3K/mTOR Inhibitor-12 (compound 48; 72 h) exhibits anticancer activity with IC50 values of 0.07 μM for PC-3, 0.09 μM for HT-29, 0.54 μM for both HCT116 and LOVO, and 0.68 μM for HUVEC cells [1]. Additionally, at 0.25 to 1 μM concentrations over 12 to 48 hours, it effectively suppresses PI3K and mTOR activation in HCT116 and HT-29 cells [1].
In vivo
PI3K/mTOR Inhibitor-12 (compound 48; 20 mg/kg; orally, daily for 14 days) effectively suppressed the growth of HCT116 tumor xenografts in female BALB/c nude mice [1]. In male SD rats, the inhibitor (1 and 5 mg/kg, intravenously and orally) showed rapid plasma clearance (1428 mL/h/kg), a short half-life (T 1/2) of 2.33 hours, and an AUC (0-∞) of 1356 h·ng/mL [1].
Chemical Properties
Molecular Weight611.62
FormulaC27H27F2N9O4S
Cas No.2891692-83-2
SmilesCOC1=C(C=C(C=N1)C2=NN3C(=NC=C3C4=CN(N=N4)CCCN5CCOCC5)C=C2)NS(=O)(=O)C6=C(C=C(C=C6)F)F
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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