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glycine
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Catalog No. T2O2728Cas No. 56-40-6
Alias Glycosthene, Glycolixir, Glycocoll, Aminoacetic acid, 2-Aminoacetic acid
glycine (2-Aminoacetic acid) is a non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter.
glycine
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Purity: 99.39%
Catalog No. T2O2728Alias Glycosthene, Glycolixir, Glycocoll, Aminoacetic acid, 2-Aminoacetic acidCas No. 56-40-6
glycine (2-Aminoacetic acid) is a non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 500 mg | $41 | In Stock | In Stock | |
| 1 g | $48 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.39%
Appearance:Solid
Color:White
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Product Introduction
glycine AI Summary
glycine shows significant bioactivity across multiple domains. It demonstrates binding affinity for the glycine binding site of the NMDA receptor, with reported IC50 values ranging from 86.0 nM to 690.0 nM and a Ki value of 125.89 nM. It inhibits the binding of [3H]5,7-dichlorokynurenic acid and [3H]MK 801 to NMDA receptors, with various EC50 values highlighting its potency across different receptor subunits (NR2A, NR2B, NR2C, and NR2D). glycine exhibits activity in inhibiting the [3H]strychnine binding to glycine receptors (IC50 of 6000.0 nM), GABA transporters (with IC50 values between 1.35µM and 3.1µM), and human LAT1 transporters. It also shows cytotoxicity against drug-resistant KBV1 cells at very high concentrations (>50,000,000.0 nM).
Further, glycine demonstrates anticonvulsant and antiepileptic activities by reducing seizure incidence in various tests, such as the MES and strychnine tests, and it also exhibits analgesic effects in mice. The compound has potential antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity and Ebola viral entry. Biochemical assays reveal it as a potential HDAC6 inhibitor and an antagonist at human glycine alpha-1 receptor with EC50 values around 94,000.0 nM.
The physico-chemical properties include a pKa value of 9.8, a logP value of 3.21, and significant human intestinal absorption at 1.0%. Lastly, glycine exhibits a broad spectrum of interactions with various transporters and enzymes, indicating its diverse potential as a pharmacological agent..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | glycine (2-Aminoacetic acid) is a non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter. |
| Targets&IC50 | MT2 receptor:9.8(pKi), MT1 receptor:9.45(pKi) |
| Synonyms | Glycosthene, Glycolixir, Glycocoll, Aminoacetic acid, 2-Aminoacetic acid |
| Molecular Weight | 75.07 |
| Formula | C2H5NO2 |
| Cas No. | 56-40-6 |
| Smiles | O=C(O)CN |
| Relative Density. | 1.595 g/cm3 |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: Insoluble H2O: 100 mg/mL (1332.09 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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