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Necrostatin 2 racemate

Name: Necrostatin 2 racemate
Brand: TargetMol
SKU: T7504
Price: 59 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7504Cas No. 852391-15-2

Alias Necrostatin-2 racemate

Necrostatin 2 racemate (Necrostatin-2 racemate) is an potent and specific inhibitor of RIPK1.

Necrostatin 2 racemate

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Purity: 99.5%

Catalog No. T7504Alias Necrostatin-2 racemateCas No. 852391-15-2

Necrostatin 2 racemate (Necrostatin-2 racemate) is an potent and specific inhibitor of RIPK1.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$59	In Stock	In Stock
5 mg	$109	In Stock	In Stock
10 mg	$172	In Stock	In Stock
25 mg	$322	In Stock	In Stock
50 mg	$555	In Stock	In Stock
100 mg	$783	In Stock	In Stock
500 mg	$1,590	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$143	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.5%

Color:White to Yellow

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COA HNMR LCMS

Product Introduction

Necrostatin 2 racemate AI Summary

Necrostatin 2 racemate is a necroptosis inhibitor with bioactivity in FADD deficient Jurkat T cells treated with TNF-alpha, demonstrating an EC50 of 210.0 nM and an IC50 of 206.0 nM according to ATP-based viability assays. It inhibits human recombinant RIPK1 with an IC50 of 320.0 nM, suggesting a moderate level of inhibition in cell death and inflammation pathways. Against human recombinant AurKA and AurKB, its IC50 values are greater than 3000.0 nM, indicating low potency. In pharmacokinetic studies, it shows measurable clearance values, brain and plasma concentrations, maximum concentrations, times to reach maximum concentrations, and volume of distribution at steady state in male and female mice. Necrostatin 2 racemate exhibits minor SARS-CoV-2 3CL-Pro protease inhibition at 2.74% at 20µM and displays antiviral activity against SARS-CoV-2 in VERO-6 cells, with a minimal cytotoxicity inhibition percentage of 0.04% at 10µM for 48 hours at 0.01 MOI exposure..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Necrostatin 2 racemate (Necrostatin-2 racemate) is an potent and specific inhibitor of RIPK1.
Synonyms	Necrostatin-2 racemate

Chemical Properties

Molecular Weight	277.71
Formula	C₁₃H₁₂ClN₃O₂
Cas No.	852391-15-2
Smiles	CN1C(=O)NC(Cc2c[nH]c3c(Cl)cccc23)C1=O
Relative Density.	1.450 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (162.04 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (9 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6009 mL	18.0044 mL	36.0088 mL	180.0439 mL
5 mM	0.7202 mL	3.6009 mL	7.2018 mL	36.0088 mL
10 mM	0.3601 mL	1.8004 mL	3.6009 mL	18.0044 mL
20 mM	0.1800 mL	0.9002 mL	1.8004 mL	9.0022 mL
50 mM	0.0720 mL	0.3601 mL	0.7202 mL	3.6009 mL
100 mM	0.0360 mL	0.1800 mL	0.3601 mL	1.8004 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc