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HDL376

Name: HDL376
Brand: TargetMol
SKU: T24134
Price: 139 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T24134Cas No. 147751-31-3

Alias SDZ-HDL376, SDZHDL376, SDZ HDL376, HDL-376, HDL 376

HDL376 (SDZ HDL376) is a scavenger receptor BI inhibitor.

HDL376

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Purity: 98.35%

Catalog No. T24134Alias SDZ-HDL376, SDZHDL376, SDZ HDL376, HDL-376, HDL 376Cas No. 147751-31-3

HDL376 (SDZ HDL376) is a scavenger receptor BI inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$139	In Stock	In Stock
5 mg	$336	In Stock	In Stock
10 mg	$497	In Stock	In Stock
25 mg	$793	In Stock	In Stock
50 mg	$1,130	In Stock	In Stock
100 mg	$1,520	In Stock	In Stock
200 mg	$1,980	-	In Stock
1 mL x 10 mM (in DMSO)	$298	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:98.35%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	HDL376 (SDZ HDL376) is a scavenger receptor BI inhibitor.
In vivo	HDL376 was shown to raise HDL cholesterol in the rat (normal-fed 80 mg/kg/day), hamster (normal-fed 52 mg/kg/day, chow-fed 64 mg/kg/day), dog (normal-fed 35 mg/kg/day), rhesus monkey (12 mg/kg/day), and cynomolgus monkeymodels (12 mg/kg/day)[2].
Synonyms	SDZ-HDL376, SDZHDL376, SDZ HDL376, HDL-376, HDL 376

Chemical Properties

Molecular Weight	256.79
Formula	C₁₂H₁₇ClN₂S
Cas No.	147751-31-3
Smiles	N(C(NCC(C)C)=S)C1=C(C)C=CC(Cl)=C1
Relative Density.	1.31g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (194.71 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.79 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8942 mL	19.4712 mL	38.9423 mL	194.7116 mL
5 mM	0.7788 mL	3.8942 mL	7.7885 mL	38.9423 mL
10 mM	0.3894 mL	1.9471 mL	3.8942 mL	19.4712 mL
20 mM	0.1947 mL	0.9736 mL	1.9471 mL	9.7356 mL
50 mM	0.0779 mL	0.3894 mL	0.7788 mL	3.8942 mL
100 mM	0.0389 mL	0.1947 mL	0.3894 mL	1.9471 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc