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HDL376

Name: HDL376
Brand: TargetMol
SKU: T24134
Price: 83 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T24134Cas No. 147751-31-3

Alias SDZ-HDL376, SDZHDL376, SDZ HDL376, HDL-376, HDL 376

HDL376 (SDZ HDL376) is a scavenger receptor BI inhibitor.

HDL376

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Purity: 98.35%

Catalog No. T24134Alias SDZ-HDL376, SDZHDL376, SDZ HDL376, HDL-376, HDL 376Cas No. 147751-31-3

HDL376 (SDZ HDL376) is a scavenger receptor BI inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$83	In Stock	In Stock
5 mg	$202	In Stock	In Stock
10 mg	$298	In Stock	In Stock
25 mg	$476	In Stock	In Stock
50 mg	$678	In Stock	In Stock
100 mg	$912	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$179	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.35%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	HDL376 (SDZ HDL376) is a scavenger receptor BI inhibitor.
In vivo	HDL376 was shown to raise HDL cholesterol in the rat (normal-fed 80 mg/kg/day), hamster (normal-fed 52 mg/kg/day, chow-fed 64 mg/kg/day), dog (normal-fed 35 mg/kg/day), rhesus monkey (12 mg/kg/day), and cynomolgus monkeymodels (12 mg/kg/day)[2].
Synonyms	SDZ-HDL376, SDZHDL376, SDZ HDL376, HDL-376, HDL 376

Chemical Properties

Molecular Weight	256.79
Formula	C₁₂H₁₇ClN₂S
Cas No.	147751-31-3
Smiles	N(C(NCC(C)C)=S)C1=C(C)C=CC(Cl)=C1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (194.71 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.79 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8942 mL	19.4712 mL	38.9423 mL	194.7116 mL
5 mM	0.7788 mL	3.8942 mL	7.7885 mL	38.9423 mL
10 mM	0.3894 mL	1.9471 mL	3.8942 mL	19.4712 mL
20 mM	0.1947 mL	0.9736 mL	1.9471 mL	9.7356 mL
50 mM	0.0779 mL	0.3894 mL	0.7788 mL	3.8942 mL
100 mM	0.0389 mL	0.1947 mL	0.3894 mL	1.9471 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc