Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Insulin-degrading enzyme (IDE) is a thiol-sensitive zinc-metallopeptidase that acts as the major insulin-degrading protease in vivo, mediating the termination of insulin signaling. [1] In addition to regulating insulin action in diabetes pathogenesis, IDE plays a role in Varicella-Zoster virus infection and degradation of amyloid-β, a peptide implicated in Alzheimer's disease. ML-345 is a small molecule inhibitor that selectively targets cysteine819 in IDE with an EC50 value of 188 nM. [2] It demonstrates 10-fold selectivity for IDE over a panel of enzymes with reactive cysteine residues.[2]
Description | Insulin-degrading enzyme (IDE) is a thiol-sensitive zinc-metallopeptidase that acts as the major insulin-degrading protease in vivo, mediating the termination of insulin signaling. [1] In addition to regulating insulin action in diabetes pathogenesis, IDE plays a role in Varicella-Zoster virus infection and degradation of amyloid-β, a peptide implicated in Alzheimer's disease. ML-345 is a small molecule inhibitor that selectively targets cysteine819 in IDE with an EC50 value of 188 nM. [2] It demonstrates 10-fold selectivity for IDE over a panel of enzymes with reactive cysteine residues.[2] |
Molecular Weight | 479.55 |
Formula | C21H22FN3O5S2 |
CAS No. | 1632125-79-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: 5 mg/mL
DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL
DMSO: 1 mg/mL
You can also refer to dose conversion for different animals. More
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ML-345 1632125-79-1 ML345 ML 345 inhibitor inhibit