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PI3K/Akt/mTOR signalingMELK
Maternal embryonic leucine zipper kinase (MELK) is an enzyme that in humans is encoded by the MELK gene. MELK is a serine/threonine kinase belonging to the family of AMPK/Snf1 protein kinases. MELK was first identified present as maternal mRNA in mouse embryos. MELK expression is elevated in a number of cancers and is an active research target for pharmacological inhibition.
OTSSP167 hydrochloride
T215591431698-10-0
OTSSP167 hydrochloride is a highly potent inhibitor of MELK(IC50 : 0.41 nM).
- $34
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OTSSP167
Cited
T17591431697-89-0
OTSSP167 (OTS167) is an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity.
- $34
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CitedHTH-01-091
T241522000209-42-5In house
HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM) that also inhibits PIM1 2 3, RIPK2, DYRK3, smMLCK, and CLK2. It can be used to study breast cancer.
- $296
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NMS-P715
T122371202055-32-0
NMS-P715 is a selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).
- $72
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MELK-IN-1
T119972095596-44-2In house
MELK-IN-1 (MELK inhibitor 17) is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK),(IC50:3nm;Ki:0.39 nM).
- $30
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MELK-8a hydrochloride
T119962096992-20-8
MELK-8a hydrochloride is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK, IC50 = 2 nM).
- $30
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JNJ-47117096 hydrochloride
T117251610536-69-0
JNJ-47117096 hydrochloride is a potent and selective MELK inhibitor with an IC50 of 23 nM and also effectively inhibits Flt3 with an IC50 of 18 nM.
- $766
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JNJ-47117096
T2046071610586-62-3
JNJ-47117096 is a potent and selective MELK inhibitor with an IC50 of 23 nM, and it also exhibits strong activity against Flt3 with an IC50 of 18 nM.
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Antitumor agent-116
T79582
Antitumor Agent-116 (Compound 6C) is an anti-tumor agent that exhibits anti-proliferative properties and induces apoptosis. It demonstrates binding affinity for the MELK receptor [1].
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MELK-8a Dihydrochloride
T35342
MELK-8a Dihydrochloride is a useful organic compound for research related to life sciences and the catalog number is T35342.
- $502
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JTV-519 hemifumarate
T117321435938-25-2
JTV-519 hemifumarate,Antiarrhythmic and cardioprotective properties. is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle.
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MELK-8a
T624171922153-17-0
MELK-8a (NVS-MELK8a) is a potent and selective inhibitor of maternal embryonic leucine zipper kinase (MELK), with an IC50 of 2 nM and an IC50 of 0.42 μM in cellular assays. MELK is crucial in regulating mitosis in cancer cells.
- $1,520
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HTH-01-091 TFA
T73867
HTH-01-091 TFA, a potent and selective inhibitor of maternal embryonic leucine zipper kinase (MELK), exhibits an IC50 of 10.5 nM. Besides its primary target, it also inhibits PIM1 2 3, RIPK2, DYRK3, smMLCK, and CLK2, positioning it as a promising agent for breast cancer research [1].
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