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SLC13A5-IN-1

🥰Excellent
Catalog No. T12931Cas No. 2227548-95-8

SLC13A5-IN-1 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5) that completely blocks the uptake of 14C-citrate, with an IC50 of 0.022 μM in HepG2 cells.

SLC13A5-IN-1

SLC13A5-IN-1

🥰Excellent
Purity: 99.67%
Catalog No. T12931Cas No. 2227548-95-8
SLC13A5-IN-1 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5) that completely blocks the uptake of 14C-citrate, with an IC50 of 0.022 μM in HepG2 cells.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$43In StockIn Stock
5 mg$98In StockIn Stock
10 mg$163In StockIn Stock
25 mg$297In StockIn Stock
50 mg$497In StockIn Stock
100 mg$693In StockIn Stock
200 mg$982In StockIn Stock
500 mg$1,450In StockIn Stock
1 mL x 10 mM (in DMSO)$123In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.67%
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Product Introduction

Bioactivity
Description
SLC13A5-IN-1 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5) that completely blocks the uptake of 14C-citrate, with an IC50 of 0.022 μM in HepG2 cells.
Targets&IC50
HepG2/14C-Citrate uptake:0.022 μM , Recombinant hSLC3A5/14C-Citrate Uptake:0.056 μM
In vitro
In HepG2/14C-Citrate Uptake Assay,SLC13A5-IN-1 exhibits an IC50 of 0.022 μM . HepG2 cells endogenously express hSLC13A5 transporter which is responsible for the uptake of citrate into these cells. Uptake of 14C-citrate can be completely blocked by SLC13A5-IN-1 and the signal can be competed with unlabelled citrate.In recombinant hSLC3A5/14C-Citrate Uptake Assay, SLC13A5-IN-1 exhibits an IC50 of 0.056 μM . SLC13A5-IN-1 exhibits an IC50 of 100 μM in recombinant Human GlyT2/3H-Glycine Uptake Assay. The human embryonic kidney 293 cells are used that stably over-express the human GlyT2 receptor which is responsible for the uptake of glycine into these cells. Uptake of 3H-glycine can be completely blocked by SLC13A5-IN-1.
Chemical Properties
Molecular Weight461.79
FormulaC19H19Cl3N2O3S
Cas No.2227548-95-8
SmilesS(=O)(=O)(C1=CC(Cl)=CC(Cl)=C1)N2CCC(C(NCC3=CC=C(Cl)C=C3)=O)CC2
Relative Density.1.436 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 5 mg/ml (10.83 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1655 mL10.8274 mL21.6549 mL108.2743 mL
5 mM0.4331 mL2.1655 mL4.3310 mL21.6549 mL
10 mM0.2165 mL1.0827 mL2.1655 mL10.8274 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Keywords

UptakeStearoylCoADesaturase(SCD)StearoylCoADesaturaseStearoylCoA Desaturase (SCD)Stearoyl-CoA DesaturaseSodiumChannelSodium ChannelSLC13A5-IN-1SLC-13A5-IN-1SLC13A5IN1SLC13A5 IN 1SLC13A5SCDrecombinant hSLC3A5/14C-Citrate Uptake AssayNa+ channelsNa channelsmetabolicInhibitorinhibithuman HEPG2hSLC3A5HepG2/14C-Citrate Uptake AssaydiseaseCitratecardiovascular
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