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Nortadalafil

Name: Nortadalafil
Brand: TargetMol
SKU: T6147
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6147Cas No. 171596-36-4

Alias Demethyl Tadalafil

Nortadalafil (Demethyl Tadalafil) is demethyl Tadalafil, which is a PDE5 inhibitor, treating erectile dysfunction (ED) ; and under the name Adcirca for the treatment of pulmonary arterial hypertensio.

Nortadalafil

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Purity: 99.42%

Catalog No. T6147Alias Demethyl TadalafilCas No. 171596-36-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$31	In Stock	In Stock
2 mg	$44	In Stock	In Stock
5 mg	$72	In Stock	In Stock
10 mg	$113	In Stock	In Stock
25 mg	$213	In Stock	In Stock
50 mg	$372	In Stock	In Stock
100 mg	$597	In Stock	In Stock
200 mg	$847	-	In Stock
500 mg	$1,260	-	In Stock
1 mL x 10 mM (in DMSO)	$79	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.42%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Nortadalafil AI Summary

Nortadalafil exhibits in vitro inhibitory activity against bovine phosphodiesterase 5 with IC50 values of 11.0 nM and 12.0 nM. It shows effective concentrations against rat aortic smooth muscle cells with EC50 values of 300.0 nM and 600.0 nM. Additionally, Nortadalafil demonstrates antiplasmodial activity against the chloroquine-susceptible Plasmodium falciparum GHA strain in human erythrocytes after 72 hours with an IC50 of > 64000.0 nM, and it presents cytotoxicity against human MRC5 SV2 cells after 72 hours with an IC50 of > 64000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Nortadalafil (Demethyl Tadalafil) is demethyl Tadalafil, which is a PDE5 inhibitor, treating erectile dysfunction (ED) ; and under the name Adcirca for the treatment of pulmonary arterial hypertensio.
Synonyms	Demethyl Tadalafil

Chemical Properties

Molecular Weight	375.38
Formula	C₂₁H₁₇N₃O₄
Cas No.	171596-36-4
Smiles	O=C1CNC(=O)[C@H]2Cc3c([nH]c4ccccc34)[C@H](N12)c1ccc2OCOc2c1
Relative Density.	1.55 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (173.16 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.33 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6640 mL	13.3198 mL	26.6397 mL	133.1984 mL
5 mM	0.5328 mL	2.6640 mL	5.3279 mL	26.6397 mL
10 mM	0.2664 mL	1.3320 mL	2.6640 mL	13.3198 mL
20 mM	0.1332 mL	0.6660 mL	1.3320 mL	6.6599 mL
50 mM	0.0533 mL	0.2664 mL	0.5328 mL	2.6640 mL
100 mM	0.0266 mL	0.1332 mL	0.2664 mL	1.3320 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc