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Anti-Insulin Antibody (7U822) is a Mouse antibody targeting Insulin. Anti-Insulin Antibody (7U822) can be used in IHC-P.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 100 μL | $199 | 7-10 days | 7-10 days |
| Description | Anti-Insulin Antibody (7U822) is a Mouse antibody targeting Insulin. Anti-Insulin Antibody (7U822) can be used in IHC-P. |
| Synonyms | MODY10, IRDN, insulin, INS, ILPR, IDDM2, IDDM1, IDDM |
| Ig Type | Mouse IgG1 |
| Clone | 7U822 |
| Reactivity | Human, Cynomolgus, Mouse, Rat |
| Specificity | Human, Cynomolgus, Mouse, Rat |
| Verified Activity | 1. Immunochemical staining Insulin in human pancreas with mouse monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). 2. Immunochemical staining Insulin in cynomolgus pancreas with mouse monoclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections. 3. Immunochemical staining Insulin in rat pancreas with mouse monoclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections. 4. Immunochemical staining Insulin in mouse pancreas with mouse monoclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections. |
| Application | |
| Recommended Dose | IHC-P: 1:100-1:500 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Insulin / INS (rh Insulin / INS; TMPY-00395; P01308; Phe25-Lys53 & Gly90-Asn110). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | INS (Insulin) is a Protein Coding gene. This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. The binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Diseases associated with INS include Hyperproinsulinemia and Maturity-Onset Diabetes Of The Young, Type 10. A multitude of mutant alleles with phenotypic effects has been identified, including insulin-dependent diabetes mellitus, permanent neonatal diabetes mellitus, maturity-onset diabetes of the young type 10, and hyperproinsulinemia.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human Insulin / INS Protein (TMPY-00395) |
| Antigen Species | Human |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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