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KUS121

Name: KUS121
Brand: TargetMol
SKU: T36570
Rating: 4.5 (1 reviews)

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Catalog No. T36570Cas No. 1357164-52-3

Alias KUS-121, KUS 121

KUS121 is a valosin-containing protein modulator that inhibits VCP ATPase activity with an IC50 of 330 nM, suppresses tunicamycin-induced ATP depletion, cell death, and CHOP upregulation in HeLa cells, protects primary cortical neurons from oxygen-glucose deprivation injury in vitro, reduces infarct volume and improves motor performance in mouse models of focal cerebral ischemia, and preserves retinal structure and visual function in rd10 retinitis pigmentosa models, supporting its investigation in neuroprotection and ischemic disease research.

KUS121

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Catalog No. T36570Alias KUS-121, KUS 121Cas No. 1357164-52-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$63	35 days	35 days
5 mg	Preferential	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:Red

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Product Introduction

Bioactivity

Description	KUS121 is a valosin-containing protein modulator that inhibits VCP ATPase activity with an IC50 of 330 nM, suppresses tunicamycin-induced ATP depletion, cell death, and CHOP upregulation in HeLa cells, protects primary cortical neurons from oxygen-glucose deprivation injury in vitro, reduces infarct volume and improves motor performance in mouse models of focal cerebral ischemia, and preserves retinal structure and visual function in rd10 retinitis pigmentosa models, supporting its investigation in neuroprotection and ischemic disease research.
In vivo	In animal models of ischemic retinal injury, intravitreal (IVT) injection of KUS121 (25 ug/eye) mitigates retinal damage. The administration is associated with the suppression of inner retinal layer thinning at 7 and 14 days post-injury, preserving retinal morphology and visual function. In rd10 mice (a model for retinitis pigmentosa), KUS121 inhibits the thinning of the outer nuclear layer and maintains visual acuity. These in vivo effects are linked to the suppression of Endoplasmic Reticulum (ER) stress, characterized by reduced expression of the marker CHOP, activation of the mTOR signaling pathway, and inhibition of apoptosis [1][2][3][4].
Synonyms	KUS-121, KUS 121

Chemical Properties

Molecular Weight	458.44
Formula	C₂₂H₁₆FN₄NaO₃S
Cas No.	1357164-52-3
Smiles	O=S([O-])(C1=CC(N=NC2=CN=C(C3=C(C)C=C(F)C=C3)C=C2)=C(C4=C1C=CC=C4)N)=O.[Na+]

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 48 mg/mL (104.7 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1813 mL	10.9066 mL	21.8131 mL	109.0655 mL
5 mM	0.4363 mL	2.1813 mL	4.3626 mL	21.8131 mL
10 mM	0.2181 mL	1.0907 mL	2.1813 mL	10.9066 mL
20 mM	0.1091 mL	0.5453 mL	1.0907 mL	5.4533 mL
50 mM	0.0436 mL	0.2181 mL	0.4363 mL	2.1813 mL
100 mM	0.0218 mL	0.1091 mL	0.2181 mL	1.0907 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

KUS121