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BuChE-IN-TM-10
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Catalog No. T10630Cas No. 2313524-95-5
Alias TM-10
BuChE-IN-TM-10 (TM-10) is a potent inhibitor of butyrylcholinesterase (BuChE) with an IC50 of 8.9 nM. It effectively inhibits and disaggregates self-induced Aβ aggregation, exhibits significant antioxidant activity, and demonstrates substantial penetration through the blood-brain barrier (BBB), holding promise as a potential treatment for Alzheimer's disease.
BuChE-IN-TM-10
Copy Product Info🥰Excellent
Purity: 99.54%
Catalog No. T10630Alias TM-10Cas No. 2313524-95-5
BuChE-IN-TM-10 (TM-10) is a potent inhibitor of butyrylcholinesterase (BuChE) with an IC50 of 8.9 nM. It effectively inhibits and disaggregates self-induced Aβ aggregation, exhibits significant antioxidant activity, and demonstrates substantial penetration through the blood-brain barrier (BBB), holding promise as a potential treatment for Alzheimer's disease.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $195 | In Stock | In Stock | |
| 2 mg | $293 | In Stock | In Stock | |
| 5 mg | $448 | In Stock | In Stock | |
| 10 mg | $658 | In Stock | In Stock | |
| 25 mg | $987 | In Stock | In Stock | |
| 50 mg | $1,380 | In Stock | In Stock | |
| 100 mg | $1,890 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.54%
Appearance:Solid
Color:White
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Product Introduction
BuChE-IN-TM-10 AI Summary
BuChE-IN-TM-10 demonstrates a range of bioactivities, including the inhibition of various enzymes and effects on amyloid beta aggregation. Specifically, it inhibits equine serum butyrylcholinesterase (BChE) with an IC50 of 8.9 nM and electric eel acetylcholinesterase (AChE) with an IC50 of 12100.0 nM. Additionally, it inhibits human monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) with IC50 values of 6300.0 nM and 8600.0 nM, respectively. The compound also inhibits an unidentified source of BChE with an IC50 of 8900.0 nM. It exhibits significant activity against amyloid beta aggregation, inhibiting self-induced amyloid beta (1-42) aggregation by 53.9% at a concentration of 25 μM and disaggregating pre-formed amyloid beta aggregates by 43.8% at the same concentration. Furthermore, BuChE-IN-TM-10 has demonstrated antioxidant activity comparable to 0.53 trolox in the ORAC radical scavenging assay..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | BuChE-IN-TM-10 (TM-10) is a potent inhibitor of butyrylcholinesterase (BuChE) with an IC50 of 8.9 nM. It effectively inhibits and disaggregates self-induced Aβ aggregation, exhibits significant antioxidant activity, and demonstrates substantial penetration through the blood-brain barrier (BBB), holding promise as a potential treatment for Alzheimer's disease. |
| Targets&IC50 | BuChE:8.9 nM |
| Synonyms | TM-10 |
| Molecular Weight | 498.66 |
| Formula | C32H38N2O3 |
| Cas No. | 2313524-95-5 |
| Smiles | C(/C=C/C1=CC(OC)=C(OCCCCN(CC2=CC=CC=C2)CC)C=C1)(=O)N3CC=4C(CC3)=CC=CC4 |
| Relative Density. | 1.127 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 5.48 mg/mL (10.99 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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