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TIM-1/KIM-1/HAVCR1 Protein, Human, Recombinant (aa 21-295, His)

Catalog No. TMPK-01139
Synonyms: KIM1, TIM-1, HAVCR-1, KIM-1, TIM, TIM1, TIMD1, HAVCR, CD365, TIMD-1, HAVCR1

Kidney injury molecule 1 (KIM-1, also known as TIM-1) is markedly upregulated in the proximal tubule after injury and is maladaptive when chronically expressed. KIM-1-mediated epithelial cell phagocytosis of apoptotic cells protects the kidney after acute injury by downregulating innate immunity and inflammation.

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TIM-1/KIM-1/HAVCR1 Protein, Human, Recombinant (aa 21-295, His)
Pack Size Availability Price/USD Quantity
100 μg 5 days $ 487.00
500 μg 5 days $ 1,950.00
1 mg 5 days $ 3,250.00
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Biological Description
Technical Params
Product Properties
References and Literature
Description Kidney injury molecule 1 (KIM-1, also known as TIM-1) is markedly upregulated in the proximal tubule after injury and is maladaptive when chronically expressed. KIM-1-mediated epithelial cell phagocytosis of apoptotic cells protects the kidney after acute injury by downregulating innate immunity and inflammation.
Species Human
Expression System HEK293
Tag C-His
Accession Number Q96D42
Synonyms KIM1, TIM-1, HAVCR-1, KIM-1, TIM, TIM1, TIMD1, HAVCR, CD365, TIMD-1, HAVCR1
Construction Recombinant Human TIM-1/HAVCR1 Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Ser21-Gly295.[Accession |Q96D42]
Protein Purity > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Molecular Weight The protein has a predicted MW of 30.58 kDa. Due to glycosylation, the protein migrates to 95-115 kDa based on Tris-Bis PAGE result.
Endotoxin Less than 1EU per μg by the LAL method.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability & Storage

-20 to -80°C for 12 months as supplied from date of receipt. -20 to -80°C for 3-6 months in unopened state after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

Research Background Kidney injury molecule 1 (KIM-1, also known as TIM-1) is markedly upregulated in the proximal tubule after injury and is maladaptive when chronically expressed. KIM-1-mediated epithelial cell phagocytosis of apoptotic cells protects the kidney after acute injury by downregulating innate immunity and inflammation.

References and Literature

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Keywords

TIM-1/KIM-1/HAVCR1 Protein, Human, Recombinant (aa 21-295, His) KIM1 TIM-1 HAVCR-1 KIM-1 HAVCR 1 TIM TIM1 TIMD1 HAVCR TIMD 1 TIM 1 CD365 CD-365 CD 365 TIMD-1 HAVCR1 KIM 1 recombinant recombinant-proteins proteins protein

 

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