Anti-macro H2A.1 Antibody (8E306) is a Rabbit antibody targeting macro H2A.1. Anti-macro H2A.1 Antibody (8E306) can be used in ICC/IF, IF, IHC-Fr, IHC-P, WB.

IgG

8E306

Human,Mouse,Rat

ICC/IF=1:100-500; IF=1:200-500; IHC-Fr=1:200-500; IHC-P=1:200-500; WB=1:500-2000

Monoclonal

A synthesized peptide: human Histone mH2A1

Human

Macroh2a1

Core histone macro-H2A.1

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation. Inhibits the binding of transcription factors and interferes with the activity of remodeling SWI/SNF complexes. Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces an hypoacetylated state of chromatin. In addition, isoform 1, but not isoform 2, binds ADP-ribose and O-acetyl-ADP-ribose, and may be involved in ADP-ribose-mediated chromatin modulation.