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NE 52-QQ57

Name: NE 52-QQ57
Brand: TargetMol
SKU: T11461
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11461Cas No. 1401728-56-0

NE 52-QQ57 is a selective, orally available antagonist of GPR4 (IC50: 70 nM) with anti-inflammatory activity.

NE 52-QQ57

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Purity: 98.63%

Catalog No. T11461Cas No. 1401728-56-0

NE 52-QQ57 is a selective, orally available antagonist of GPR4 (IC50: 70 nM) with anti-inflammatory activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$42	In Stock	In Stock
5 mg	$98	In Stock	In Stock
10 mg	$163	In Stock	In Stock
25 mg	$328	In Stock	In Stock
50 mg	$496	In Stock	In Stock
100 mg	$745	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$118	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:98.63%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

NE 52-QQ57 AI Summary

NE 52-QQ57 inhibits a target protein with an IC50 value of 74.0 nM according to a Radio Ligand Binding Assay, indicating potent binding affinity. It exhibits antinociceptive activity in a Wistar Han rat model of mechanical hyperalgesia with an ED50 of 14.7 mg/kg. The compound antagonizes mouse and human GPR4, with IC50 values of 530.0 nM and 67.0 nM, respectively. Additionally, it inhibits VEGF-induced angiogenesis by 46.8% at 30 mg/kg for 4 days and shows moderate inhibitory effects in arthritic models and ERG expression in HEK293 cells. NE 52-QQ57 affects cell viability variably across different cell types, promotes or inhibits cell growth in a cell-type specific manner, and impacts the thermal stability of protein domains. It demonstrates significant activity in GPCR beta-arrestin recruitment assays, notably inhibiting FFAR4 and ADRB2 targets. These findings suggest potential therapeutic applications in pain, inflammation, and angiogenesis, with complex interactions affecting various molecular pathways..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	NE 52-QQ57 is a selective, orally available antagonist of GPR4 (IC50: 70 nM) with anti-inflammatory activity.
Targets&IC50	GPR4:70 nM

Chemical Properties

Molecular Weight	416.52
Formula	C₂₄H₂₈N₆O
Cas No.	1401728-56-0
Smiles	CCc1nn2c(C)cc(C)nc2c1Cc1ccc(cc1)-c1nnc(o1)C1CCNCC1
Relative Density.	1.32 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 9.7 mg/mL (23.29 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.4 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4008 mL	12.0042 mL	24.0085 mL	120.0423 mL
5 mM	0.4802 mL	2.4008 mL	4.8017 mL	24.0085 mL
10 mM	0.2401 mL	1.2004 mL	2.4008 mL	12.0042 mL
20 mM	0.1200 mL	0.6002 mL	1.2004 mL	6.0021 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc