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BC1618

🥰Excellent
Catalog No. T8929Cas No. 2222094-18-8
Alias 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-

BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) is an orally active Fbxo48 inhibitor that stimulates Ampk-dependent signaling. It promotes mitochondrial fission, promotes autophagy and improves hepatic insulin sensitivity.

BC1618

BC1618

🥰Excellent
Purity: 99.95%
Catalog No. T8929Alias 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-Cas No. 2222094-18-8
BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) is an orally active Fbxo48 inhibitor that stimulates Ampk-dependent signaling. It promotes mitochondrial fission, promotes autophagy and improves hepatic insulin sensitivity.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$30In StockIn Stock
5 mg$76In StockIn Stock
10 mg$122In StockIn Stock
25 mg$247In StockIn Stock
50 mg$422In StockIn Stock
100 mg$628In StockIn Stock
1 mL x 10 mM (in DMSO)$84In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.95%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) is an orally active Fbxo48 inhibitor that stimulates Ampk-dependent signaling. It promotes mitochondrial fission, promotes autophagy and improves hepatic insulin sensitivity.
In vivo
BC1618, whose potency in stimulating Ampk-dependent signaling greatly exceeds 5-aminoimidazole-4-carboxamide-1-β-ribofuranoside (AICAR) or metformin.?This compound increases the biological activity of Ampk not by stimulating the activation of Ampk, but rather by preventing activated pAmpkα from Fbxo48-mediated degradation.?Consistenting with augmenting Ampk activity, BC1618 promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity in high-fat-diet-induced obese mice[1].
Synonyms2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-
Chemical Properties
Molecular Weight415.45
FormulaC24H24F3NO2
Cas No.2222094-18-8
SmilesOC(COc1ccc(cc1)C(F)(F)F)CN(Cc1ccccc1)Cc1ccccc1
Relative Density.1.223 g/cm3 (Predicted)
ColorBlack
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (240.70 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4070 mL12.0351 mL24.0703 mL120.3514 mL
5 mM0.4814 mL2.4070 mL4.8141 mL24.0703 mL
10 mM0.2407 mL1.2035 mL2.4070 mL12.0351 mL
20 mM0.1204 mL0.6018 mL1.2035 mL6.0176 mL
50 mM0.0481 mL0.2407 mL0.4814 mL2.4070 mL
100 mM0.0241 mL0.1204 mL0.2407 mL1.2035 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

Ubiquitin ligaseUbiquitin conjugating enzymeUbiquitin activating enzymepS6pAmpkmTORCMitophagyMitochondrial AutophagymitochondrialmetforminLPSinsulinInhibitorinhibitfissionFbxo48E3EnzymeE3 ligating enzymeE3 EnzymeE2EnzymeE2 EnzymeE2 conjugating enzymeE1EnzymeE1/E2/E3 EnzymeE1 EnzymeE1 activating enzymeBC-1618BC1618BC 1618AMPKAMP-activated protein kinase
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