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Anti-Phospho-SNCA (Ser129) Antibody (6F53)
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Catalog No. TMAH-00968
Alias SNCA (p-Ser129), SNCA (p-S129), p-SNCA (Ser129), p-SNCA (S129), Phospho-SNCA (S129), PD1, PARK4, PARK1, NACP
Anti-Phospho-SNCA (Ser129) Antibody (6F53) is an antibody targeting Phospho-SNCA (Ser129). Anti-Phospho-SNCA (Ser129) Antibody (6F53) can be used in ELISA,IF,IHC.
Anti-Phospho-SNCA (Ser129) Antibody (6F53)
Anti-Phospho-SNCA (Ser129) Antibody (6F53)
😃Good
Catalog No. TMAH-00968Alias SNCA (p-Ser129), SNCA (p-S129), p-SNCA (Ser129), p-SNCA (S129), Phospho-SNCA (S129), PD1, PARK4, PARK1, NACP
Anti-Phospho-SNCA (Ser129) Antibody (6F53) is an antibody targeting Phospho-SNCA (Ser129). Anti-Phospho-SNCA (Ser129) Antibody (6F53) can be used in ELISA,IF,IHC.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $207 | 7-10 days | 7-10 days | |
| 100 μL | $348 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
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Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Phospho-SNCA (Ser129) Antibody (6F53) is an antibody targeting Phospho-SNCA (Ser129). Anti-Phospho-SNCA (Ser129) Antibody (6F53) can be used in ELISA,IF,IHC. |
| Synonyms | SNCA (p-Ser129), SNCA (p-S129), p-SNCA (Ser129), p-SNCA (S129), Phospho-SNCA (S129), PD1, PARK4, PARK1, NACP |
| Ig Type | Rabbit IgG |
| Clone | 6F53 |
| Reactivity | Human |
| Verified Activity | 1. IHC image of TMAH-00968 diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. 2. Immunofluorescence staining of Hela cells(treated with 100mM EGF for 20min) with TMAH-00968 at 1:206,counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L). |
| Application | |
| Recommended Dose | IHC:1:50-1:200; IF:1:20-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cytoplasm. Membrane. Nucleus. Cell junction, synapse. Secreted. |
| Tissue Specificity | Highly expressed in presynaptic terminals in the central nervous system. Expressed principally in brain. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human Phospho-SNCA (S129) |
| Antigen Species | Human |
| Gene Name | SNCA |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Neuroscience |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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